Protein Info for TX73_025120 in Rhodopseudomonas palustris CGA009

Annotation: peptide-methionine (S)-S-oxide reductase MsrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00401: peptide-methionine (S)-S-oxide reductase
  • amino acids 47 to 201 (155 residues), 214.4 bits, E=4.8e-68
• PF01625: PMSR
  • amino acids 47 to 201 (155 residues), 205.7 bits, E=2.3e-65

Best Hits

Swiss-Prot: 70% identical to MSRA_METNO: Peptide methionine sulfoxide reductase MsrA (msrA) from Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060)

KEGG orthology group: K07304, peptide-methionine (S)-S-oxide reductase [EC: 1.8.4.11] (inferred from 100% identity to rpt:Rpal_5321)

MetaCyc: 62% identical to methionine sulfoxide reductase A (Escherichia coli K-12 substr. MG1655)
L-methionine (S)-S-oxide reductase. [EC: 1.8.4.13]; Peptide-methionine (S)-S-oxide reductase. [EC: 1.8.4.13, 1.8.4.11]

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11)" (EC 1.8.4.11)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.4.11

Use Curated BLAST to search for 1.8.4.11 or 1.8.4.13

Protein Sequence (218 amino acids)

>TX73_025120 peptide-methionine (S)-S-oxide reductase MsrA (Rhodopseudomonas palustris CGA009)
MFFMRKSTAMPSAAEALPGRPTPIPTARTHFVSGNRLQPPFPEGLQQAVFGLGCFWGAER
KFWQLGDGVYSTAVGYAGGFTPNPTYEEVCSGRTGHTEVVLVVFDPARISYEALLKTFWE
SHDPTQGMRQGNDVGSQYRSAIYTFGDDQKRAAEASRVTYGDALKAKGYGPITTEIAASG
PFYYAEDYHQQYLAKNPGGYCGLGGTGVSCPVGVRVTA