Protein Info for TX73_024545 in Rhodopseudomonas palustris CGA009

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1025 PF02739: 5_3_exonuc_N" amino acids 34 to 200 (167 residues), 184.9 bits, see alignment E=1.9e-58 TIGR00593: DNA polymerase I" amino acids 35 to 1025 (991 residues), 899.7 bits, see alignment E=1.3e-274 PF01367: 5_3_exonuc" amino acids 201 to 296 (96 residues), 105.4 bits, see alignment E=3.8e-34 PF01612: DNA_pol_A_exo1" amino acids 415 to 609 (195 residues), 56.2 bits, see alignment E=8.1e-19 PF00476: DNA_pol_A" amino acids 642 to 1023 (382 residues), 520 bits, see alignment E=7.2e-160

Best Hits

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1025 amino acids)

>TX73_024545 DNA polymerase I (Rhodopseudomonas palustris CGA009)
MPKTTKSAAATPAASSVTPPAPVGVKPPGKGDHIFLVDGSSYIFRAYHALPPLNRKSDGL
QVNAVLGFCNMLWKLLRDMPPENRPTHLAIIFDKSEVTFRNHLYPEYKAHRPPAPEDLIP
QFALIREAVRAFDLPCLEQSGFEADDLIATYVREACEAGATATIVSSDKDLMQLVTDCVV
MYDTMKDRRIGVPEVIEKFGVPPNKVVEVQALAGDSVDNVPGVPGIGIKTAAQLINEYGD
LETLLARAPEIKQPKRREALIENAEKARISRKLVLLDDHVQLEVPLEELAVHEPDARKLV
AFLKAMEFTTLTRRVADYAQIDPSDVEAETALKSAVPPLAKSAAASGDLFAGQEPSPQPS
PASGGGSALASGQGGPLNAGRGRDGRPGVVLSPEALVAARAEAARKIPVDRTAYKTLRSL
DELHGFIARIHDTGIVALETVATSIDPMQAELIGLALALGPNDACYIPLLHKQSGDGDGL
FAAGLAPDQIGPRDALDALKPILESAGVAKVGFAIKFAAVLLAQHGLTLRNIDDPQLMSY
ALDAGRGSHALDALSESNLGHTLHTLTELTGTGKNKIGFDQVPVDRATAYAAERADVSLR
LARVLKPRLVAGSMTAVYETLERPLVGVLARMERRGISIDRQVLSRLSADFAQTAARIEA
EIRELAGEDINIGSPKQLGDILFGKMGLPGGSKTKTGAWSTSAQVLDELAEQGHEFPRKI
LDWRQVSKLRSTYTDALPNYVHPQTHRVHTTYALAATTTGRLSSNEPNLQNIPVRTEDGR
KIRRAFVATPGNKLVSADYSQIELRLLSEVADVPALRKAFQDGIDIHAMTASEMFGVPVE
GMPSEIRRRAKAINFGIIYGISAFGLANQLSIPREEAGAYIKRYFERFPGIRAYMDETRD
FCRNHGYVTTLFGRKCHYPDIKASNPSIRAFNERAAINARLQGSAADIIRRAMVRMEDAL
AEKKLSAQMLLQVHDELIFEVPEAEVEATLPVVRAVMQDAPFPAVILNVPLQVDARAADN
WDEAH