Protein Info for TX73_022385 in Rhodopseudomonas palustris CGA009

Annotation: alpha-hydroxy acid oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01070: FMN_dh
  • amino acids 15 to 377 (363 residues), 463.3 bits, E=1.2e-142
• PF01645: Glu_synthase
  • amino acids 299 to 339 (41 residues), 22.5 bits, 1.5e-08

Best Hits

Swiss-Prot: 47% identical to LLDD_CAUSK: L-lactate dehydrogenase (lldD) from Caulobacter sp. (strain K31)

KEGG orthology group: K00101, L-lactate dehydrogenase (cytochrome) [EC: 1.1.2.3] (inferred from 100% identity to rpa:RPA4320)

Predicted SEED Role

"L-lactate dehydrogenase (EC 1.1.2.3)" in subsystem L-rhamnose utilization or Lactate utilization or Respiratory dehydrogenases 1 (EC 1.1.2.3)

MetaCyc Pathways

• methylglyoxal degradation V (1/3 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (3/8 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.2.3

Protein Sequence (379 amino acids)

>TX73_022385 alpha-hydroxy acid oxidase (Rhodopseudomonas palustris CGA009)
MKEITCIEDLRQIHKRRVPKMFFDYVDHGSYAEETLRANVDDLKRIKFRQRILVDISKRD
LATTILGDTYAMPLILAPVGSTGMQHADGEIHACRAAQAAGIPYTLSTMSICSIEDVAAN
VEKPFWFQLYVMRDRGFAKALIERAIAAKCSALVLTVDLQVIGQRHQDIKNGMTVPPQLF
KLKNVIDIATKPRWVKGILGTPRRNFGNIAGHLPGSKDLESVSAWVASQFDASLNWRDID
WIRSIWPGKLIIKGILDVEDAREAVKVGAEALVVSNHGGRQLDGAPSSIEVLPEIVHTVG
SHIEVMFDGGIRSGQDVMRALALGAKSCMIGRAYIYGLGAYGGPGVAKAIDIIGKELSTT
MGLCGVNSIHEIDEKVLAD