Protein Info for TX73_022060 in Rhodopseudomonas palustris CGA009

Annotation: NADH-quinone oxidoreductase subunit NuoH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00146: NADHdh
  • amino acids 12 to 309 (298 residues), 371.9 bits, E=1.3e-115

Best Hits

Swiss-Prot: 100% identical to NUOH2_RHOPA: NADH-quinone oxidoreductase subunit H 2 (nuoH2) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K00337, NADH dehydrogenase I subunit H [EC: 1.6.5.3] (inferred from 100% identity to rpt:Rpal_4737)

MetaCyc: 52% identical to NADH:quinone oxidoreductase subunit H (Escherichia coli K-12 substr. MG1655)
NADH-DEHYDROG-A-RXN [EC: 7.1.1.2]; 7.1.1.- [EC: 7.1.1.2]

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain H (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• NADH to dimethyl sulfoxide electron transfer (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NADH to fumarate electron transfer (1/2 steps found)
• NADH to hydrogen peroxide electron transfer (1/2 steps found)
• NADH to trimethylamine N-oxide electron transfer (1/2 steps found)
• nitrate reduction VIII (dissimilatory) (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3 or 7.1.1.2

Protein Sequence (319 amino acids)

>TX73_022060 NADH-quinone oxidoreductase subunit NuoH (Rhodopseudomonas palustris CGA009)
MIGMIITATISVALIMVLLVLAGTFTWVERRLLGFVQERYGPNRVGPFGSLQWVADTVKI
LTKEDRPPPGADKLLYILAPAVAATPVLAGFGVVAIGDGWALSSVDVGLLFLLGMLGLTA
YAAVLGAWASNNRFSLLGGMRAAAQMLAYEVFLGLSLMGVVMIAGSFSMAEIVEAQRGVW
FVVLQPLGMALFTIAGIAAAHRLPFDLPESENDLIAGFITEYTGMSFGLFFLGEYLAVLL
VSALAVTLFFGGWLGPWLPGPVWFGLKTAVIAVAFVWIRATLPRPRYDQLLSFAWKVALP
LSLLNLMLTGIVVVARSAS