Protein Info for TX73_021765 in Rhodopseudomonas palustris CGA009

Annotation: haloacid dehalogenase type II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 248 PF00702: Hydrolase" amino acids 5 to 187 (183 residues), 102.4 bits, see alignment E=4.3e-33 TIGR01428: haloacid dehalogenase, type II" amino acids 5 to 197 (193 residues), 207 bits, see alignment E=5.7e-65 TIGR01493: HAD hydrolase, family IA, variant 2" amino acids 7 to 186 (180 residues), 102.5 bits, see alignment E=5.7e-33 PF13419: HAD_2" amino acids 94 to 193 (100 residues), 40 bits, see alignment E=4.6e-14 TIGR01509: HAD hydrolase, family IA, variant 3" amino acids 95 to 193 (99 residues), 37.9 bits, see alignment E=4e-13

Best Hits

Swiss-Prot: 57% identical to HAD_XANAU: (S)-2-haloacid dehalogenase (dhlB) from Xanthobacter autotrophicus

KEGG orthology group: K01560, 2-haloacid dehalogenase [EC: 3.8.1.2] (inferred from 100% identity to rpa:RPA4199)

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.8.1.2

Use Curated BLAST to search for 3.8.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (248 amino acids)

>TX73_021765 haloacid dehalogenase type II (Rhodopseudomonas palustris CGA009)
MPHMIKAVVFDAYGTLYDIQSVATVTEREFPGYGEVITQIWRIKQLEYTWLRSQMGTYED
FAVVTRDSLAYTLDCLGIEAGGGAFERIFAKYLDLTLYPEALAALEALASCKRAILSNGS
PDMLGALTRNTGLDRVLDDVISVDAAKVFKPHPRAYALAEARLGVAPREMLFVSSNPWDV
AGAKAFGFNVAWIERVSREAMARELRRPGPLPPQTLFKALRTQMDVLGFEPDHRIGSLTA
LVEIVAGR