Protein Info for TX73_020770 in Rhodopseudomonas palustris CGA009

Annotation: HWE histidine kinase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 682 PF01590: GAF" amino acids 37 to 165 (129 residues), 43 bits, see alignment E=1.6e-14 amino acids 350 to 476 (127 residues), 32.3 bits, see alignment E=3.4e-11 PF13185: GAF_2" amino acids 339 to 475 (137 residues), 34.2 bits, see alignment E=7.1e-12 PF07536: HWE_HK" amino acids 493 to 571 (79 residues), 74.2 bits, see alignment E=2.9e-24 PF07568: HisKA_2" amino acids 493 to 557 (65 residues), 24.9 bits, see alignment E=4.5e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to rpa:RPA4009)

Predicted SEED Role

"signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (682 amino acids)

>TX73_020770 HWE histidine kinase domain-containing protein (Rhodopseudomonas palustris CGA009)
MSEAGAERPSPPRWDEQERLSALERYGILDTPREPDFDDIVQLAADTFGAPIAAVNLIAS
GRQWFKAEIGLGARELPLDVSICAHAIVQSGTMVVPDTRLDARFVDNPLVTAAGGLRFYA
GALLKTPEGLPLGTVCVLDREPRPAGISDLQRRTLEVLARLVMTQLEMRRVIALQDAHAR
QLEAEMRERKHAEAARRSSDDRYRALFDSIDTGFCIIEVAFGADGVASDYQFIETNSAFM
QQTGLADVEGKWMRQLAPGHEQYWFDTYGEVARSGIPIRFKKPAKALDDRWFDVHAFRIG
DPGDRLVAVLFNDITARRRGELRRDALLKMGDQLRSLTTIQDMTGIASEIVGRALGAVRA
GFGRVDPGEESVIIENDWSAAGYASLAGWHSLSDHPSFETANATKQPVVVADVAAAPPDN
LSSQAKDDPGIGSLAVIPIENHDGSTALFFVHVAEPRDWSDDDLAFLRNVGDRLAAGVGR
LDAEALQHTLNLELSHRMKNTLAMVMAIARQTLRSIPDQAPVEAFNARLQALSTAHMALL
QQHWTAAKINEVVKGVVGAVEGLDRFTISGPAVSLGARATLSSSLLLHELATNALKYGAL
SAPTGRVTISWKVADEQLIIEWRETGGPAITPPTHKGFGSRLIQLGLIGTGGVELRYLAS
GFEADFSAPLSQVQERNAGENR