Protein Info for TX73_020725 in Rhodopseudomonas palustris CGA009

Annotation: adenylate/guanylate cyclase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1105 signal peptide" amino acids 1 to 15 (15 residues), see Phobius details transmembrane" amino acids 761 to 779 (19 residues), see Phobius details PF12773: DZR" amino acids 3 to 46 (44 residues), 33 bits, see alignment (E = 1.6e-11) PF00211: Guanylate_cyc" amino acids 73 to 237 (165 residues), 73 bits, see alignment E=7.8e-24 PF13191: AAA_16" amino acids 270 to 448 (179 residues), 76.6 bits, see alignment E=9.9e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to rpa:RPA4000)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1) / Guanylate cyclase (EC 4.6.1.2)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1, EC 4.6.1.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1, 4.6.1.2

Use Curated BLAST to search for 4.6.1.1 or 4.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1105 amino acids)

>TX73_020725 adenylate/guanylate cyclase domain-containing protein (Rhodopseudomonas palustris CGA009)
MRCSACGLSAPTEASFCPRCGAKLSLHCQSCGFRSPLGSHFCGGCGASLVEASGTTVTGV
SGGIAPDRDQRPERRQVTILFVDMIGSTEMSVRLDEEEFKDIIYRYRDICANAVRQFDGC
IVRYIGDGILVCFGFPFAHEDDPIRAARAGLALLDNLQRLNSEQETKAIQVRMGMHTGIV
IAGDLRSSDTFEAMGILGETPNIASRVQNLAAPDRLVITLETAQLLGERFDLIDLGLQQA
RGVDGPLHLFEVAGERTEATRERPPASHKMIGRQQELALLQDRFFRAQDGEGQVVQIIAE
AGAGKTRLVREFKARLDPAAFLPMTCYCSAYSRSSAFYPIIEMIRRVVKPDGDADAEAMS
ANLQRSFVGLETITPEATALVAELLELPVSPAIKDIPPARRRELLLEVLTQWVLKQSEDV
PVILVVEDLHWADASTTTLLRHIVERLSNWRVMTIFTFRPELTAEWLLGSQVTRLGLRRL
SKNEARALTAQIAEASTMTADIIASIVAKTGGIPLFIEELTKAVLAGASSADHDPARLTA
LVDSIPSTLRGSLAARLDRLQIAKPLAQVAATLGRTFDSKVLAAVTGESQPALRAQLDEL
LRQGFIHQHGTQVQAKYSFKHALIQEAAYDSLLKSERRSMHRRIAEVISTQFADVVAATP
EVLAEHYAAAELAESAIAHWEAAGNKAAERSANVEAASHFANALAVLRRMPDTTERARRE
LSLELQRGSQLLAIKGNAAPQVEEVFTRAYQLSWRLGEHRLLFRALYGLMMFFIVRGQLE
KAHQCGVRLIEQAERAGDDGLQLQAKRPLGLTQFYLGQFSSAKETLKQALQLYDPDRHHH
HRFEYGSDPAVLAQCNLAWTEWFVGLPDTAIADSAQAMARAIQLNHPHSLGFALSFEASI
RQSRGEPKEALQAAEQAIQIGQSYRFPYWSAWGRILRGWAIGRLDSPASGAAEIKAGLED
YRATGAELIRPYGLMLLAETLGTDGALEDALALLNEALDITETNRTLFCGPELYRLRGSL
LLAADSHDDAGGENLRKAVDLAHELGSPMLELRALASLVSASPPRGSSAPLQRLERLRDA
MTEGFATADLAEVARVIELAATHRR