Protein Info for TX73_020640 in Rhodopseudomonas palustris CGA009

Annotation: nucleoside-diphosphate sugar epimerase/dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 46 to 67 (22 residues), see Phobius details amino acids 82 to 103 (22 residues), see Phobius details amino acids 117 to 138 (22 residues), see Phobius details PF00106: adh_short" amino acids 295 to 407 (113 residues), 28.9 bits, see alignment E=2.8e-10 PF04321: RmlD_sub_bind" amino acids 296 to 421 (126 residues), 34.7 bits, see alignment E=3.7e-12 PF02719: Polysacc_synt_2" amino acids 297 to 592 (296 residues), 345.7 bits, see alignment E=7.1e-107 PF01370: Epimerase" amino acids 297 to 518 (222 residues), 64.6 bits, see alignment E=3.5e-21 PF08659: KR" amino acids 297 to 419 (123 residues), 23.1 bits, see alignment E=2.2e-08 PF01073: 3Beta_HSD" amino acids 298 to 426 (129 residues), 23.5 bits, see alignment E=9.6e-09 PF16363: GDP_Man_Dehyd" amino acids 299 to 421 (123 residues), 39.1 bits, see alignment E=2.4e-13

Best Hits

KEGG orthology group: K13013, O-antigen biosynthesis protein WbqV (inferred from 100% identity to rpa:RPA3983)

Predicted SEED Role

"UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)" in subsystem N-linked Glycosylation in Bacteria (EC 4.2.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.-

Use Curated BLAST to search for 4.2.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (639 amino acids)

>TX73_020640 nucleoside-diphosphate sugar epimerase/dehydratase (Rhodopseudomonas palustris CGA009)
MLTSIRSFTYRNWLIALHDLLATAAAVLLSFYLRFDGENLLDRLPLLLKILPYFVVFSFF
VCYLFQLTTTKWRFISIPDLLNILRAASVLTIALLVLDYIFLAPNMYGTFFLGKTTIVLY
WFLEVFFLAGSRLAYRYFRYTRTRNKARRLDAAPTLLIGRAADAEVFLRAVESGAVQRLW
PVGILSPAFSDRGQTIRGLPVLGGIDDLHNVIADFAHRNRPIERAVMMPSAFDAEAQPES
VLMRARKLGLTVSRLPSLEESRDTPRLAPVAVEDLLLRPSVKIDYDRLEGLLKGKSIVVT
GGGGSIGFEMCDRVTTFGAARLLVIENSEPALYAAMEKLLAKVSKTKVEGRIADIRDRDR
VFDLIGAFKPDLVFHAAALKHVPILERDWGEGVKTNIFGSVNVADAARASGAEAMVMIST
DKAIEPVSMLGLTKRFAELYCQALDRELTTSVGDKPAMRLISVRFGNVLASNGSVVPKFK
AQIEAGGPVTVTHPDMVRYFMTIREACDLVITAATHALRSRHADASVFVLSMGQPVKIVE
LAERMIRLSGLQPGYDIEIVFTGVRPGERLHEILFAEHEPTTEIGIPGIMAACPNELPLA
TLRQGLTALETAIAAGCHDEVVAILKGAVPEFRIEPTAP