Protein Info for TX73_019580 in Rhodopseudomonas palustris CGA009

Annotation: FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 405 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details PF07992: Pyr_redox_2" amino acids 4 to 301 (298 residues), 238.1 bits, see alignment E=6.8e-74 PF00070: Pyr_redox" amino acids 145 to 226 (82 residues), 65.4 bits, see alignment E=2.5e-21 PF14759: Reductase_C" amino acids 320 to 403 (84 residues), 102.2 bits, see alignment E=8e-33

Best Hits

Swiss-Prot: 52% identical to THCD_RHOER: Rhodocoxin reductase (thcD) from Rhodococcus erythropolis

KEGG orthology group: K00529, ferredoxin--NAD+ reductase [EC: 1.18.1.3] (inferred from 100% identity to rpa:RPA3782)

MetaCyc: 39% identical to NADH-putidaredoxin reductase (Pseudomonas putida ATCC 17453)
RXN-13138 [EC: 1.18.1.5]

Predicted SEED Role

"Ferredoxin reductase" in subsystem Anaerobic respiratory reductases

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.18.1.3 or 1.18.1.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (405 amino acids)

>TX73_019580 FAD-dependent oxidoreductase (Rhodopseudomonas palustris CGA009)
MNDTVLIAGAGHAGFQVAVSLRQAKYPGRIALINDEKHLPYQRPPLSKAYLKSGGDPNSL
MFRPEKFFQDQAIELISDRMVSIDREGRKLLLASGTAIEYGHLVLATGARNRMLDVPNAS
LPDVLYLRTLDESEVLRQRMPDKKHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMA
RVVTPEISSYFHDRHSGAGIRMHYGVRATEIAAEGDRVTGVVLSDGNTLPCDLVVVGVGV
IPNVEIAAAAGLPTAAGIIVDQQLLTSDPHISAIGDCALFESVRFGETMRVESVQNATDQ
ARCVAARLTGDAKPYDGYPWFWSDQGDDKLQIVGLTAGFDQVVIRGSVAERSFSAFCYKA
GKLIGIESVNRAADHVFGRKILPLDKSVTPEQAADLSFDLKKAAA