Protein Info for TX73_018840 in Rhodopseudomonas palustris CGA009

Annotation: decarboxylating 6-phosphogluconate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 TIGR00872: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 1 to 323 (323 residues), 408 bits, see alignment E=1.1e-126 PF03807: F420_oxidored" amino acids 2 to 58 (57 residues), 27.6 bits, see alignment E=7.2e-10 PF03446: NAD_binding_2" amino acids 2 to 153 (152 residues), 130.6 bits, see alignment E=1.2e-41 PF02254: TrkA_N" amino acids 6 to 67 (62 residues), 24.7 bits, see alignment E=5.2e-09 PF00393: 6PGD" amino acids 185 to 310 (126 residues), 79.7 bits, see alignment E=5.1e-26

Best Hits

Swiss-Prot: 66% identical to 6PGDH_GLUOX: 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating (GOX1705) from Gluconobacter oxydans (strain 621H)

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 99% identity to rpt:Rpal_4156)

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (346 amino acids)

>TX73_018840 decarboxylating 6-phosphogluconate dehydrogenase (Rhodopseudomonas palustris CGA009)
MQIGMIGLGRMGGNIVRRLMKDGHHAVVYDRDPQAIETLTREGATGAGGLEDLVRKLDAP
RAVWVMLPAGQITETTIEQLAKLLAAGDVVIDGGNTFWQDDIRRAKTLKETSIDYVDVGT
SGGIWGFERGYCMMIGGDKAVVDRLDPIFATLAPGIGDIPRTPGRDDRDPRVEQGYLHAG
PVGAGHFVKMVHNGIEYGLMQAYAEGFDILKNASSDSLPEAHRFDLDIADIAEVWRRGSV
IPSWLLDLTATALAKNDQLDNYSGFVEDSGEGRWTINAAIEEAVPAEVLTAALFARFRSR
REHTFAEKILSAMRAGFGGHKEPQQHPEPEQQAAPQQKLKPKAERA