Protein Info for TX73_018165 in Rhodopseudomonas palustris CGA009

Annotation: UvrD-helicase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 848 PF00580: UvrD-helicase" amino acids 38 to 284 (247 residues), 237.1 bits, see alignment E=7.4e-74 amino acids 318 to 350 (33 residues), 42.9 bits, see alignment (E = 1.3e-14) PF13245: AAA_19" amino acids 42 to 274 (233 residues), 58.3 bits, see alignment E=2.3e-19 PF13361: UvrD_C" amino acids 355 to 685 (331 residues), 227.8 bits, see alignment E=6.7e-71

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to rpa:RPA3506)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (848 amino acids)

>TX73_018165 UvrD-helicase domain-containing protein (Rhodopseudomonas palustris CGA009)
MTDPTKRQPLDLSSYQPAAGGIAARARAAAGPAYLSGLNPEQREAVETLDGPVLVLAGAG
TGKTRVLTTRIAHILSTGRARPAEILSVTFTNKAAREMKLRLGQMLGQAVEGMPWLGTFH
SIGGRILRYHAELVQLTSNFTVLDTDDQIRLLKQLLAADNIDDKRWPARMLAGLIDGWKN
RGLTPSQVPAGEAAMFGNGRGGKLYAQYQERLKILNAADFGDLLLENIRLFREHPDVLRS
YQNRFKFILVDEYQDTNVAQYLWLRLLSQTPSSSSLPGSTRQSISSQEDGSPGLAASRRP
GDDVETSGNVVASTSAPPKNICCVGDDDQSIYGWRGAEVDNILRFDHDFPGAKVIRLERN
YRSTGHILAAASHLIAHNEGRLGKTLRTEDVDGEMVTVTGAWDSEEEARAIGEEIEQLQR
QGHALNEIAILVRASFQMREFEDRFVTLGLPYRVIGGPRFYERAEIRDALAYLRVINSPA
DDLAFERIVNVPKRGLGDATVQMLHDHARKRRIPLFDAARMVIDTDELKPKARGSLRGLI
ESFERWQVQRDAVAHTELAEIVLDESGYTEMWQKDRSADAAGRLENLKELVRSMEEFENL
QGFLEHISLVMDREGGADEDAVSVMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEQGRA
GLEEERRLAHVGITRARKRAKLYFATNRRIHGTWNTTIPSRFLDELPAANVEITESKGGS
GWGGMSGYGPSRFDNVESFGSSYSTPGWQRAQAQRGRSGGGSNGGRSGGFGESSSSYSSG
STRRAPFTIEGELVAKSTGTESAFSLKDRVFHQKFGYGHVTKIDGNKLTIVFDKAGEKKV
VDSFVERA