Protein Info for TX73_016345 in Rhodopseudomonas palustris CGA009
Annotation: aldo/keto reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 40% identical to DKGA_CORSC: 2,5-diketo-D-gluconic acid reductase A (dkgA) from Corynebacterium sp. (strain ATCC 31090)
KEGG orthology group: K00011, aldehyde reductase [EC: 1.1.1.21] (inferred from 100% identity to rpa:RPA3161)MetaCyc: 40% identical to 2,5-diketo-D-gluconate reductase A monomer (Corynebacterium sp. SHS 0007)
RXN0-7020 [EC: 1.1.1.346]
Predicted SEED Role
"oxidoreductase, aldo/keto reductase family"
MetaCyc Pathways
- methylglyoxal degradation III (1/2 steps found)
- D-arabinose degradation V (1/3 steps found)
- D-galactose degradation IV (1/3 steps found)
- L-arabinose degradation II (1/3 steps found)
- L-ascorbate biosynthesis VIII (engineered pathway) (3/7 steps found)
- ketogluconate metabolism (3/8 steps found)
- superpathway of methylglyoxal degradation (3/8 steps found)
- detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
- superpathway of pentose and pentitol degradation (9/42 steps found)
KEGG Metabolic Maps
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Pentose and glucuronate interconversions
- Pyruvate metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.21
Use Curated BLAST to search for 1.1.1.21 or 1.1.1.346
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (277 amino acids)
>TX73_016345 aldo/keto reductase (Rhodopseudomonas palustris CGA009) MQTADAHFVEAHGAKIPALGLGTWELSGHSCSRIVEQALRLGYRHIDTAQIYDNEREVGE GIRNSHIRRDQLFVTTKVWTTHFAPNDLVRSAKESLVKLRLSEVDLLLLHWPNAHVPLAE TLGALAQARALGLTRHIGVSNFTVALLAEAVAVCPAPLVCNQVEYHPFLDQQKVLAACAL YGMALVAYSPIARGNAKKSEVLTRIGNVHGKTAAQVCLRWLIQQNVAAIPRSSRLERLAQ NIDVFDFELSDAEMQEIFTLGSPKGRLTTMPTAPVWD