Protein Info for TX73_015345 in Rhodopseudomonas palustris CGA009

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 810 PF02190: LON_substr_bdg" amino acids 18 to 208 (191 residues), 186.3 bits, see alignment E=2.1e-58 TIGR00763: endopeptidase La" amino acids 19 to 775 (757 residues), 1011 bits, see alignment E=2.4e-308 PF00004: AAA" amino acids 358 to 495 (138 residues), 82.9 bits, see alignment E=8.8e-27 PF07728: AAA_5" amino acids 358 to 482 (125 residues), 32 bits, see alignment E=3.4e-11 PF05362: Lon_C" amino acids 575 to 777 (203 residues), 324.9 bits, see alignment E=5.7e-101 PF13541: ChlI" amino acids 620 to 745 (126 residues), 33.5 bits, see alignment E=1.1e-11

Best Hits

Swiss-Prot: 82% identical to LON_AZOC5: Lon protease (lon) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 91% identity to bbt:BBta_4570)

MetaCyc: 64% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (810 amino acids)

>TX73_015345 endopeptidase La (Rhodopseudomonas palustris CGA009)
MTATKPRPSITYGESHSYPVLPLRDIVVFPHMIVPLFVGREKSIRALEEVMKNDALIMLA
TQKNASDDDPAPDAIYEIGTLASVLQLLKLPDGTVKVLVEGLARAKVDKYTDRADYYEAD
AVALEDSDATSVEAEALGRSVVSDFESYVKLNKKISAEVVGVVQSITDFAKLADTVASHL
AVKIADRQGILETLSVTQRLEKVLGLMESEISVLQVEKRIRSRVKRQMEKTQREYYLNEQ
MKAIQKELGDEDGRDELAELEEKIAKTKLSKEAREKAQHELKKLRQMSPMSAEATVVRNY
LDWLLSIPWNKKSKVKKDLEAAQAVLDSDHYGLEKVKERIVEYLAVQSRANKLSGPILCL
VGPPGVGKTSLGKSIAKATGREFVRVSLGGVRDEAEIRGHRRTYIGSMPGKIIQSMRKAK
TSNPLFLLDEIDKMGADFRGDPSSALLEVLDPEQNGTFNDHYLEVDYDLSNVMFITTANT
LNIPGPLMDRMEIIRIAGYTETEKVEIARKHLIPLALTKHGLEPKEWSIDDNALLLVIRR
YTREAGVRNLEREISTLARKVVKDLMLSKKKSVHIDEKQIEEYLGVPKFRFGEIEKDDQV
GVVTGLAWTDVGGELLTIESVMMPGKGRMTVTGNLRDVMKESIQAAASYVRSRAITFGIE
PPFFEKRDIHVHVPEGATPKDGPSAGVAMATTIVSVLTGIPIRRDIAMTGEITLRGRVLP
IGGLKEKLLAAARGGIKTVLIPEDNAKDLTEISDAIKGGLNIIPVARMDEVIANALTRAP
VPIVWEEETKLPGTPDSAEADEAGGGLTAH