Protein Info for TX73_014555 in Rhodopseudomonas palustris CGA009

Annotation: nucleoside triphosphate pyrophosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00444: MazG family protein
  • amino acids 13 to 268 (256 residues), 300.7 bits, E=4.5e-94
• PF03819: MazG
  • amino acids 30 to 103 (74 residues), 103.7 bits, E=5e-34
  • amino acids 175 to 237 (63 residues), 36.8 bits, E=3.8e-13
• PF01503: PRA-PH
  • amino acids 155 to 219 (65 residues), 24.8 bits, E=2.3e-09

Best Hits

Swiss-Prot: 50% identical to MAZG_ECO57: Nucleoside triphosphate pyrophosphohydrolase (mazG) from Escherichia coli O157:H7

KEGG orthology group: K02428, nucleoside-triphosphate pyrophosphatase [EC: 3.6.1.19] (inferred from 100% identity to rpa:RPA2811)

MetaCyc: 50% identical to nucleoside triphosphate pyrophosphohydrolase (Escherichia coli K-12 substr. MG1655)
Nucleotide diphosphatase. [EC: 3.6.1.9]

Predicted SEED Role

"Nucleoside triphosphate pyrophosphohydrolase MazG (EC 3.6.1.8)" (EC 3.6.1.8)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (5/7 steps found)
• dZTP biosynthesis (3/5 steps found)
• pyrimidine deoxyribonucleotides dephosphorylation (1/3 steps found)
• tunicamycin biosynthesis (1/9 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Nicotinate and nicotinamide metabolism
• Pantothenate and CoA biosynthesis
• Purine metabolism
• Pyrimidine metabolism
• Riboflavin metabolism
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.19 or 3.6.1.8 or 3.6.1.9

Protein Sequence (274 amino acids)

>TX73_014555 nucleoside triphosphate pyrophosphohydrolase (Rhodopseudomonas palustris CGA009)
MTPSRDIARLIEIMAALRTPVTGCPWDLEQDFATIAPYTIEEAFEVAEAISRHDLDDLRE
ELGDLLLQVVFHARIAEERGAFAFGDVVEAITRKMIRRHPHVFADADGNLTPSHVEGVWD
RIKAEEKAERAARRGLTEQPSSSVLAGVKSGQPALSRAMDLQRKAAKVGFDWNDPRAVLA
KIREETDEIEAALDRGDQAHITEETGDLLFALVNLARHAKADPEIALRGANAKFERRFAY
IEQALAAQGRTPDDATLAEMDALWNEAKTTEATK