Protein Info for TX73_013780 in Rhodopseudomonas palustris CGA009

Annotation: bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01173: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase
  • amino acids 8 to 439 (432 residues), 480.3 bits, E=3e-148
• PF00483: NTP_transferase
  • amino acids 8 to 157 (150 residues), 33.4 bits, E=9.3e-12
• PF01128: IspD
  • amino acids 8 to 130 (123 residues), 35.4 bits, E=2.5e-12
• PF12804: NTP_transf_3
  • amino acids 9 to 136 (128 residues), 62.5 bits, E=1.4e-20
• PF00132: Hexapep
  • amino acids 269 to 302 (34 residues), 30.2 bits, 6.3e-11
  • amino acids 304 to 335 (32 residues), 27.5 bits, see alignment (E = 4.6e-10)
  • amino acids 381 to 415 (35 residues), 35.4 bits, 1.5e-12
• PF14602: Hexapep_2
  • amino acids 381 to 415 (35 residues), 31.9 bits, 2.3e-11

Best Hits

Swiss-Prot: 100% identical to GLMU_RHOPA: Bifunctional protein GlmU (glmU) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K04042, bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC: 2.3.1.157 2.7.7.23] (inferred from 100% identity to rpa:RPA2659)

Predicted SEED Role

"N-acetylglucosamine-1-phosphate uridyltransferase (EC 2.7.7.23) / Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)" in subsystem Peptidoglycan Biosynthesis or Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.3.1.157, EC 2.7.7.23)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (3/6 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (3/7 steps found)
• chitin biosynthesis (4/9 steps found)
• peptidoglycan recycling I (7/14 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (5/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.157 or 2.7.7.23

Protein Sequence (452 amino acids)

>TX73_013780 bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU (Rhodopseudomonas palustris CGA009)
MTARNSLTIVLAAGEGTRMRSSLPKVLNPVAGRSLLAHVLSAAPHGERDRLAVVIGPDHQ
AVGDEAKRVRSDAAIHIQAQRLGTAHAVLAAREAIAQGADDLLIAFGDTPLISAETFARL
REPLHDGSSLVVLGFRAADPTGYGRLVVQDGKLTAIREQADASADELKITLCNAGVMAID
GKIALDVLDKIGNANAKGEYYLTDAVGIVRDLGLTASVIETSEDEVRGINTKAQLAEAET
VMQTRLRLAAMAAGVTLIAPETVYLAADTTFGKDVVIEPFVVIGPGVSIADGAVIHSFSH
LTEAKIGSKAQVGPYARLRPGTSLGDGAKIGNFVETKAAQIDAGAKVNHLTYIGDAHIGA
SANIGAGTITCNYDGFDKHKTEIGAGAFIGSNSSLVAPVKIGTGAYVGSGSVITKDVPDG
ALAVERNVQTAKDGWAKRFRDAKSRHRKPKAH