Protein Info for TX73_013235 in Rhodopseudomonas palustris CGA009

Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 16 to 391 (376 residues), 330.3 bits, E=5.9e-103
• TIGR01324: cystathionine beta-lyase
  • amino acids 17 to 393 (377 residues), 508.8 bits, E=3.7e-157

Best Hits

Swiss-Prot: 55% identical to METC_RHIL3: Putative cystathionine beta-lyase (metC) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 100% identity to rpa:RPA2559)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Cysteine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.8

Protein Sequence (398 amino acids)

>TX73_013235 cystathionine beta-lyase (Rhodopseudomonas palustris CGA009)
MDASDSSGTPAPLSTQTRLVTAGRDTAAQKGFVNPPVVHGSTVLYPTAADLHAHRGEYSY
GRHGTPTTKALQQALIALEGPQCAGVGITPSGVSAISTALLAVVKAGDHVLVCDNAYRPT
RLFCDQMLNRLGVETSYFDPLIGAGIASHLRPNTVAVVVEAPGSQSFEMPDIPAIAAVAK
QHGALVIDDNTWATPLYHRSLEQGVDISIQAATKYIGGHSDIMFGTVSANAAAWPKVSEA
IRLLGVCAGPDDVFLALRGLRTLEVRLARHYQAGLDMARWLTARPEVQRVLHPGLDTDPG
HAIWKRDFTGASGLFSIVLQPAPQAAVDALLDTVSLFGMGYSWGGFESLVIPFDCASYRT
ATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR