Protein Info for TX73_010800 in Rhodopseudomonas palustris CGA009

Annotation: cobyric acid synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 524 PF13500: AAA_26" amino acids 27 to 264 (238 residues), 53.9 bits, see alignment E=3.2e-18 PF01656: CbiA" amino acids 29 to 273 (245 residues), 72.6 bits, see alignment E=4.6e-24 TIGR00313: cobyric acid synthase CobQ" amino acids 29 to 518 (490 residues), 404.2 bits, see alignment E=4.2e-125 PF07685: GATase_3" amino acids 289 to 477 (189 residues), 177.5 bits, see alignment E=3.6e-56

Best Hits

Swiss-Prot: 56% identical to COBQ_RHOCB: Cobyric acid synthase (cobQ) from Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to rpa:RPA2096)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.10

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (524 amino acids)

>TX73_010800 cobyric acid synthase (Rhodopseudomonas palustris CGA009)
MTDAHVEELISRIQFTPRTTTGPRRARSLMIQGTSSDVGKSMVVAGLCRAFSRRGLVVRP
FKAQNMSNNAAVASDSDLPLGPNGELVRGEIGRAQALQARACRVAPSIHMNPVLLKPQSE
IGAQVVLRGRVLGNCPARIYHHMRQRLIPAVVDSFERLTAEADLVLVEGAGSGAEVYLRA
SDITNMRFAEAADLPVVFLSDIDRGGTMAALVGSYVLLSEGDRARVVGYLINKFRGDFSL
FEPGCRTITEQTGWPFLGVLRWFPGADRLPAEDSLALERAAAASRGRLKIAVPRLQRVAN
FDDLDPLVAEPDIDLQWIQPGSPIPADVDVVVLPGSKATRTELDLMRREGWDIDIHAHVR
RGGRVVGLCAGFQMLGKVVRDPQGIEGPAGETAGLGLLDIETEISGDKRLIEIDAVDRIS
GCRVVGYEMHMGRTTGAGLARPWLRLEEGGSERAEGAVSADGRVSGGYLHGIFGGDAFRS
AWLAQIGAASSGLDFERRVEETLDALADHCESNLDLDALLALAR