Protein Info for TX73_010220 in Rhodopseudomonas palustris CGA009

Annotation: glutathione-disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 461 TIGR01424: glutathione-disulfide reductase" amino acids 4 to 449 (446 residues), 620.5 bits, see alignment E=7.1e-191 PF07992: Pyr_redox_2" amino acids 7 to 320 (314 residues), 228.1 bits, see alignment E=4e-71 PF13738: Pyr_redox_3" amino acids 126 to 304 (179 residues), 57.2 bits, see alignment E=4.3e-19 PF00070: Pyr_redox" amino acids 171 to 242 (72 residues), 78.3 bits, see alignment E=1.3e-25 PF02852: Pyr_redox_dim" amino acids 340 to 448 (109 residues), 120.9 bits, see alignment E=7.4e-39

Best Hits

Swiss-Prot: 41% identical to GSHR_STRTR: Glutathione reductase (gor) from Streptococcus thermophilus

KEGG orthology group: K00383, glutathione reductase (NADPH) [EC: 1.8.1.7] (inferred from 100% identity to rpt:Rpal_2196)

Predicted SEED Role

"Glutathione reductase (EC 1.8.1.7)" in subsystem Glutathione: Redox cycle (EC 1.8.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (461 amino acids)

>TX73_010220 glutathione-disulfide reductase (Rhodopseudomonas palustris CGA009)
MADFDADLFVIGGGSGGVRAARIAAGYGARVVVAEEYRFGGTCVIRGCVPKKLMVYASQV
HEEIRDAAGFGWSIPTAEFNWSALIANKDKEIARLEQIYANNVEKAGARTIKARAVFDDP
HTLLLSTGEKVRAKTILIATGGAPNHGKPIPGIEHVISSNEVFHLPQQPKRILIQGGGYI
ALEFACIFAGLGSDVTLVYRGDNILRGFDEDVRTHVRTEMERAGITIITGCTVTAVEKLG
EEYTSHLSSGSSIASDQVMFAIGRHPAVASLGLEKAGVAINPDNGGIAVDDHCRTSVPHI
YAVGDVTHRTNLTPVAIREGHAFADNVFGGKQIQVDYAYVPTAVFSQPQVGTVGLTEAQA
RAQYSVVDIYKTDFRPMKGTMSGSQSRVLMKLIVDGTTDRLLGCHIVGPDAAELVQVVAV
AMKMKATKADFDGTMALHPTAAEELVTMRTRTARYQREAAE