Protein Info for TX73_009410 in Rhodopseudomonas palustris CGA009

Annotation: methylmalonyl Co-A mutase-associated GTPase MeaB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00750: LAO/AO transport system ATPase
  • amino acids 20 to 326 (307 residues), 368.4 bits, E=1.2e-114
• PF03308: MeaB
  • amino acids 25 to 295 (271 residues), 395 bits, E=7e-123

Best Hits

Swiss-Prot: 61% identical to Y2483_CAUVC: Putative GTPase CC_2483 (CC_2483) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K07588, LAO/AO transport system kinase [EC: 2.7.-.-] (inferred from 100% identity to rpt:Rpal_2033)

MetaCyc: 55% identical to methylmalonyl-CoA mutase-interacting GTPase YgfD (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]

Predicted SEED Role

"putative periplasmic protein kinase ArgK and related GTPases of G3E family"

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
• Lipopolysaccharide biosynthesis
• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.-.-, 3.6.1.15

Use Curated BLAST to search for 2.7.-.- or 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6

Protein Sequence (329 amino acids)

>TX73_009410 methylmalonyl Co-A mutase-associated GTPase MeaB (Rhodopseudomonas palustris CGA009)
MNSARRTGDIAHFASEVRSGHRAALARAITLIESRRADHQASARALVQDLLPETGRAIRV
GITGSPGVGKSTTIDALGMYLIEQGHKVAVLAVDPSSARTGGSILGDKTRMARLSAEPDA
FIRPSPSSGTLGGVAAKTREAMLLCEAAGFDVVLVETVGIGQSETAVCDMTDFFLALMLP
GAGDELQGIKKGLVELADMIAINKADGDNIKRANLAAGEYRAALHILTPRSPNWQPPVKT
YSAMTGTGIAELWQAILDHRAATTPSGEFDARRREQQVKWMWTLLEDRWKAKLRSDPAIR
AKVKSTEAAVAEGSITPTLGADRVAELIG