Protein Info for TX73_009300 in Rhodopseudomonas palustris CGA009

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1040 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 335 to 354 (20 residues), see Phobius details amino acids 361 to 380 (20 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 450 to 471 (22 residues), see Phobius details amino acids 483 to 506 (24 residues), see Phobius details amino acids 538 to 558 (21 residues), see Phobius details amino acids 879 to 898 (20 residues), see Phobius details amino acids 905 to 927 (23 residues), see Phobius details amino acids 933 to 955 (23 residues), see Phobius details amino acids 976 to 996 (21 residues), see Phobius details amino acids 1008 to 1034 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 3 to 1039 (1037 residues), 866 bits, see alignment E=1.9e-264 PF00873: ACR_tran" amino acids 5 to 1031 (1027 residues), 768.2 bits, see alignment E=6.2e-235

Best Hits

KEGG orthology group: None (inferred from 100% identity to rpt:Rpal_2011)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1040 amino acids)

>TX73_009300 CusA/CzcA family heavy metal efflux RND transporter (Rhodopseudomonas palustris CGA009)
MGRLVELAVNRRFLMLALFLLVLAGGVAAFEHLNIEAYPDPTPPMVDIVTQSPGLSAEEI
ERYITIPIETQVAGIKNLKTIRTISLYGLSDVKLQFSFDYTYQQALQQVLNRLSQLPPLP
GNVQPGISPLSPIGEIFRYRLVGPPGYSVLDLKTLQDWVLQRRFRAIPGVIDVTGWGGKT
KTYEVQVDFNKLIAYGLTLPQVLQAVSNSNINVGGNTVDIGAQSAVVRGVGLIRSLDDLA
NTMVVSNNGNPVLVKDVAKVSVAEKPRLGIAGINNDDDIVQGIVLMRRGEQSSPTIARVE
QAVTKINASGVLPPGVRIERIYDRKDLIDTTTHTVLHNMVVGILLIVLLQWIFLGDLRSA
LIVGATIPFALFFAVIILVLRGESANLLSVGAIDFGLIVDATVIMVEAIFRRLSHTTVLS
PEERSQISADTIMGMKKHAIRSAAADVSRSIFFAAAIIIAAFLPLFTLSGVEGNIFGPMA
RTYAYALAGGLLATFTVTPALSAIILPHHVQETETWLMRMLHKVYTPWLGWAVKNRPVVM
AGAAGLVLTTVIATRFLGLEFLPKLEEGNLWIRATLPPTISLTEGNGYVNDMRKLIAGFP
EVESVVSQHGRPDDGTDAAGFFNAEFFAPLKPASQWPGSHDKDELTARMLKQLQAKFPGV
EFNFSQYLQDNVSEAVSGVKGENSIKLYGNDLQALTDTANKIKAVLSTVQGVQDLAVFTS
LGQPTIQIDVNRARAARYGLTPGDINATIKVAIGGDSAGDLYEPGSDRHFPIIVRLAPEY
RKSAEAIHNLRIGVQGPNGITQIPLSELADIQLVSGAAYIYREDQERYLPIKFSVRERDL
GSAIREAQEKVNAQVQLPPGSRMEWVGEFGNLQDAIKRLSIVVPISLALIGALLFFNFGS
LTDTLLAMSVIPMAIFGGVMGLLVSGIPFSVSAAIGFIALFGIAVMDGIIILSQYNQLID
QGLDRLRAVVRTGELQLRPVLMTCVIAGVGLLPAAMSTGIGSQVQKPLAIVVVTGMMLAP
GVILITLPVLISYFSRRRAN