Protein Info for TX73_009275 in Rhodopseudomonas palustris CGA009

Annotation: error-prone DNA polymerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1195 PF02811: PHP" amino acids 11 to 105 (95 residues), 30.2 bits, see alignment E=1.4e-10 TIGR00594: DNA polymerase III, alpha subunit" amino acids 231 to 1087 (857 residues), 476.8 bits, see alignment E=8e-147 PF07733: DNA_pol3_alpha" amino acids 352 to 606 (255 residues), 298.6 bits, see alignment E=1.2e-92 PF17657: DNA_pol3_finger" amino acids 609 to 783 (175 residues), 181.8 bits, see alignment E=1.7e-57 PF14579: HHH_6" amino acids 915 to 964 (50 residues), 34.1 bits, see alignment (E = 6.3e-12) PF01336: tRNA_anti-codon" amino acids 1055 to 1125 (71 residues), 42.4 bits, see alignment 1.4e-14

Best Hits

Swiss-Prot: 100% identical to DNAE2_RHOPA: Error-prone DNA polymerase (dnaE2) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

Predicted SEED Role

"Error-prone repair homolog of DNA polymerase III alpha subunit (EC 2.7.7.7)" (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1195 amino acids)

>TX73_009275 error-prone DNA polymerase (Rhodopseudomonas palustris CGA009)
MSARYAEIGVTTNFSFLEGGSHPQDYVHEASRLGLDAIGIADRNTLAGVVRAFSEFDNEE
LIHKPKLLIGTRLCFADGTPDLLAYPTDRAAYGRLCRLLSAGKLRAGKGECHLTFADLEA
FIHERSPSIHELATVIHPPSASINQPSASIHQFPTPSWPGLTRPSTPTSKVVLVSVDARV
KPGHDGGKRVADNSQILLVVMPSYRFQTKTIAIALERLTALNADAVWLGLTPYYRGDDKR
RLARLRRIAAVARVPCIATNDVLYHHPRRRALQDVLTCVREKTSIDKAGRRLEGNAERHL
KPAAEMARLFRHDPEAIAETLRFADRISFTLDELKYHYPDEPVPPGKTAQAHLQDLTEQG
IKQYFPNGISDRLRATIAKELAIIERRGYAHYFLTVHDIVRYARSQDILCQGRGSAANSA
VCYVLGITCVDPTEIDLLFERFVSEERDEPPDIDVDFEHSRREEVMQYIYRRYGRHRAAI
VATVIHYRPRSAIRDVGKALGLSEDVTAALADTVWGSWGKGLNEMQVRQAGLDPHNPMIG
RAVELATELIGFPRHLSQHVGGYVLTQDRLDSYVPIGNAAMADRTFIEWDKDDIDAVKMM
KVDVLALGMLTCIRKGFHLIAQHKGVRFQLSDIKSEDDNAVYKMLQRGESIGVFQVESRA
QMNMLPRLKPRCFYDLVIEVAIVRPGPIQGDMVHPYLRRRNGQEPVVYPSPSGEAGDKNE
LRQILGKTLGVPLFQEQAMRIAIEAAHFTPDEANQLRRAMATFRNVGTIGKFEAKMIGNL
VKRGYDATFAKNCFEQIKGFGSYGFPESHAASFAKLVYVSAWMKCEHPDAFCCALLNSQP
MGFYAPAQIVGDARSNGVEVRPVDVSFSEGQCTLEERCGRHHAVRLGFRMIDGFRWADPD
EERVQLEAGEPPSDDWAARIVAARARGAFTSLEQFARITALPKRALILLADADAFRSLGL
DRRAALWAVRRLPDDVPLPLFEAASAREQEDERAAPLPAMPMAEHVVADYQTVRLSLKGH
PMEFLRALFAAERVVTCREVSRSEQRASGCWLRCAGVVLVRQRPGSANGVIFMTIEDETG
IANIVVWPAVMEKYRKEVMGARLVLVEGKVQASAEGVVHLVAERLIDRSAEMGRLAEGLV
RPALPDGADLYEPLTSEKYNYEALNGDRRDTPDAPAQRHRHPRDVRILPPSRDFH