Protein Info for TX73_005785 in Rhodopseudomonas palustris CGA009

Annotation: ATP-dependent zinc metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 638 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 103 to 124 (22 residues), see Phobius details PF06480: FtsH_ext" amino acids 9 to 97 (89 residues), 55 bits, see alignment E=2.6e-18 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 104 to 597 (494 residues), 786 bits, see alignment E=7.4e-241 PF07728: AAA_5" amino acids 191 to 313 (123 residues), 29.7 bits, see alignment E=1.8e-10 PF00004: AAA" amino acids 192 to 324 (133 residues), 163.5 bits, see alignment E=1.1e-51 PF17862: AAA_lid_3" amino acids 347 to 390 (44 residues), 59.3 bits, see alignment 6.4e-20 PF01434: Peptidase_M41" amino acids 406 to 595 (190 residues), 237.6 bits, see alignment E=3.3e-74

Best Hits

Swiss-Prot: 71% identical to FTSH_BARBK: ATP-dependent zinc metalloprotease FtsH (ftsH) from Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to rpt:Rpal_1317)

MetaCyc: 59% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (638 amino acids)

>TX73_005785 ATP-dependent zinc metalloprotease FtsH (Rhodopseudomonas palustris CGA009)
MNANLRNFALWVIIVLLLLALFTLFQNPGQRTASQEIPFSQLLSEIDQNHVRDVVIQGQE
IRGTFTNGSTFQTYAPNDPSLVTRLYNGKVSITAKPPGDNVPWFVSLLVSWLPFIALIGV
WIFLSRQMQGGAGKAMGFGKSRAKMLTEAHGRVTFEDVAGVDEAKQDLQEIVEFLRDPGK
FQRLGGRIPRGVLLVGPPGTGKTLIARAVAGEANVPFFTISGSDFVEMFVGVGASRVRDM
FEQAKKNAPCIIFIDEIDAVGRHRGAGLGGGNDEREQTLNQLLVEMDGFEANEGVILIAA
TNRPDVLDPALLRPGRFDRQVVVPNPDVVGREQILKVHVRKVPLAPDINLKNIARGTPGF
SGADLMNLVNEAALMAARRNKRMVTQSEFEDAKDKVMMGAERKSLVMTEEEKLLTAYHEG
GHAIVGLNVPATDPIHKATIIPRGRALGMVMQLPERDKLSMSLEQMTSRLAIMMGGRVAE
EMVFGREKVTSGAASDIEQATKLARMMVTRWGLSEELGTVAYGENQDEVFLGMSVSRTQN
ASEATIQKIDAEIKRLVEEGYNEAKRILTERRADLEALAKGLLEYETLTGDEITDLINGK
KPNRESVLEPSGPRTSAVPPAGKPRPRPDPGLEPQPQA