Protein Info for TX73_005425 in Rhodopseudomonas palustris CGA009

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 74 to 368 (295 residues), 324.5 bits, E=3.3e-101
• PF02445: NadA
  • amino acids 77 to 366 (290 residues), 371 bits, E=2e-115

Best Hits

Swiss-Prot: 67% identical to NADA_SINFN: Quinolinate synthase A (nadA) from Sinorhizobium fredii (strain NBRC 101917 / NGR234)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 99% identity to rpt:Rpal_1247)

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• NAD de novo biosynthesis I (6/6 steps found)
• NAD de novo biosynthesis III (5/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (5/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (370 amino acids)

>TX73_005425 quinolinate synthase NadA (Rhodopseudomonas palustris CGA009)
MPLAELYGPENFGLPPHARQGSLPRAPLSATERARALPMPSLEWTPEVEAATAHLYEKVQ
NVVPPVEWPFMAPYVKAINELKRERDAVILAHNYQTPEIFHCVADIVGDSLQLAIEATKV
KASTIVQCGVHFMAETSKILNPEKRVLIPDSRAGCSLASSITGADVRLLREKFPGVPVVA
YVNTSADVKAEVDICCTSSNAVQVVESLGVDRVIMVPDQYLAKYVASQTKVKIIAWKGAC
EVHERFTGDELRVYREADPSVKIIAHPECPPDVLAEADFTGSTAHMINWVKTQHPKRVVM
ITECSMADNVQAELRDVEMVRPCNLCPHMKRITLAKILDSLVYLREEVTVDPAIIAPARR
SVERMINLNN