Protein Info for TX73_004400 in Rhodopseudomonas palustris CGA009

Annotation: 5-aminolevulinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01821: 5-aminolevulinic acid synthase
  • amino acids 1 to 401 (401 residues), 684.2 bits, E=2.8e-210
• PF00155: Aminotran_1_2
  • amino acids 46 to 390 (345 residues), 243.3 bits, E=2.4e-76

Best Hits

Swiss-Prot: 83% identical to HEM1_BRADU: 5-aminolevulinate synthase (hemA) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

KEGG orthology group: K00643, 5-aminolevulinate synthase [EC: 2.3.1.37] (inferred from 100% identity to rpt:Rpal_0922)

MetaCyc: 54% identical to 5-aminolevulinate synthase 2 (Cereibacter sphaeroides)
5-aminolevulinate synthase. [EC: 2.3.1.37]

Predicted SEED Role

"5-aminolevulinate synthase (EC 2.3.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 2.3.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glycine (7/8 steps found)
• tetrapyrrole biosynthesis II (from glycine) (4/4 steps found)
• 2-amino-3-hydroxycyclopent-2-enone biosynthesis (2/4 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (17/26 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Porphyrin and chlorophyll metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.37

Use Curated BLAST to search for 2.3.1.37

Protein Sequence (409 amino acids)

>TX73_004400 5-aminolevulinate synthase (Rhodopseudomonas palustris CGA009)
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQ
HPKVVGAMVETATRIGTGAGGTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQT
GLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRHNDTAHLEELLIAAGPDRPKL
IAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWE
RERHQDRAARVKAVLNNAGIPVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINY
PTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLPLGAKAIAAE