Protein Info for TX73_002265 in Rhodopseudomonas palustris CGA009

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 883 PF08364: IF2_assoc" amino acids 17 to 51 (35 residues), 31.7 bits, see alignment (E = 4.8e-11) TIGR00487: translation initiation factor IF-2" amino acids 298 to 883 (586 residues), 776.2 bits, see alignment E=2.6e-237 PF04760: IF2_N" amino acids 304 to 354 (51 residues), 43.7 bits, see alignment 6.3e-15 TIGR00231: small GTP-binding protein domain" amino acids 382 to 540 (159 residues), 108.2 bits, see alignment E=3.7e-35 PF00009: GTP_EFTU" amino acids 383 to 541 (159 residues), 118.4 bits, see alignment E=1e-37 PF01926: MMR_HSR1" amino acids 384 to 491 (108 residues), 41.5 bits, see alignment E=4.8e-14 PF11987: IF-2" amino acids 665 to 773 (109 residues), 137.1 bits, see alignment E=9.2e-44 PF03144: GTP_EFTU_D2" amino acids 804 to 871 (68 residues), 41.4 bits, see alignment 5.6e-14

Best Hits

Swiss-Prot: 100% identical to IF2_RHOPA: Translation initiation factor IF-2 (infB) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 100% identity to rpt:Rpal_0440)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (883 amino acids)

>TX73_002265 translation initiation factor IF-2 (Rhodopseudomonas palustris CGA009)
MVDTKTPGDKTLTMPTKTLTLKPRVEQGVVRQSFSHGRSKQVVVEKRGKRRLGGDEPAAP
AAPEVAKKPAPAPAAPPRQQQSRPAPQQSRSGMVLRTLTEDERTARATALADARVREIEE
RKQAEIEAQRRAEQEKIEKAEREAAEARRKAEEERHRQEDEAKRKAETEAKKRFGDAEPA
KKPAETSTTTTTAAPARPATTTTRTPTPAGRPPAVAAEAGDDDEAPRMIRRPGGPARPAP
PPKQPAAKPGASKQRGRLTVVTALNADDVRERSIASFRRRTQRLKGHASNEPKEKLVREV
VIPEVIAIQELANRMSERAVDVIRLLMKQGAMHKITDVIDADTAQLIAEELGHTVKRVAA
SDVEEGLFDVVDDSTDTEPRSPVVTVMGHVDHGKTSLLDALRHANVVSGEAGGITQHIGA
YQVTSPESGKKITFIDTPGHAAFTAMRARGAKVTDIVVLVVAADDGVMPQTIEAINHAKA
AGVPIIVAINKIDKPDAKPDRVRTDLLQHNVQVESMGGDVVDVEVSAKNKINLDKLLEMI
ALQAEILELKTNTQRPAEGTVIEAKLDRGRGPVATVLVQRGTLRVGDIIVAGAEMGRVRA
LISDQGETVQEAGPSVPVEVLGFNGPPEAGDRLAVVENEARARQITDYRAHQKREKSAAS
VSGMRGSLEQMMTQLKTSGRKEFPLIVKADVQGSLEAILGSLEKLGTDEVAARILHAGVG
GISESDVTLAEGFNAVILGFSVRANKEAAAAAKRNGIEIRYYNIIYDLVDDIKKAMSGLL
APTLRETMLGNAQILEIFNISKVGKVAGCRVTDGTVERGANVRLIRDNVVVHEGKLSTLK
RFKDEVKEVVAGQECGMAFENYTDMRAGDIIECYRVETIQRSL