Protein Info for TX73_002195 in Rhodopseudomonas palustris CGA009
Annotation: D-glycerate dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 45% identical to GYAR_THELN: Glyoxylate reductase (gyaR) from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
KEGG orthology group: K00015, glyoxylate reductase [EC: 1.1.1.26] (inferred from 100% identity to rpa:RPA0422)Predicted SEED Role
"Glyoxylate reductase (EC 1.1.1.79) / Glyoxylate reductase (EC 1.1.1.26) / Hydroxypyruvate reductase (EC 1.1.1.81)" in subsystem Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 1.1.1.26, EC 1.1.1.79, EC 1.1.1.81)
MetaCyc Pathways
- photorespiration I (8/9 steps found)
- photorespiration III (8/9 steps found)
- photorespiration II (8/10 steps found)
- L-serine biosynthesis II (3/4 steps found)
- D-xylose degradation IV (4/7 steps found)
- formaldehyde assimilation I (serine pathway) (8/13 steps found)
- L-arabinose degradation IV (4/8 steps found)
- superpathway of pentose and pentitol degradation (9/42 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.81
Use Curated BLAST to search for 1.1.1.26 or 1.1.1.79 or 1.1.1.81
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (333 amino acids)
>TX73_002195 D-glycerate dehydrogenase (Rhodopseudomonas palustris CGA009) MSVKKKPLVVVTRKLPDSIETRMRELFDARLNLDDVPMTAEQLAEAARTADVLVPTVTDE ITAAMVNQPDCKLRLIAHFGNGIDNLDVAAAHARGITVTNTPKVLTEDTADMTMALILAV PRRMIEGAALLTDGGEWPGWSPTWMLGRRLGGKRLGIIGMGRIGQAVARRARAFGLQIHY HNRKPVAPRIADELGATYWDSLDQMLARMDIISVNCPHTPATFHLLSARRLKLVRKDAFI VNTARGEVIDEETLTKLIEAGDIAGAGLDVYEHEPAVNPKLVRLAKHGKVVLLPHMGSAT IEGRVEMGEKVIINIRTFLDNHKPPDRVLPGML