Protein Info for TX73_001850 in Rhodopseudomonas palustris CGA009

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 581 transmembrane" amino acids 38 to 57 (20 residues), see Phobius details amino acids 270 to 293 (24 residues), see Phobius details PF13755: Sensor_TM1" amino acids 24 to 87 (64 residues), 92.9 bits, see alignment E=2e-30 PF13756: Stimulus_sens_1" amino acids 122 to 231 (110 residues), 142.3 bits, see alignment E=2.1e-45 PF00672: HAMP" amino acids 288 to 341 (54 residues), 32.9 bits, see alignment 1.6e-11 PF00512: HisKA" amino acids 349 to 412 (64 residues), 58.7 bits, see alignment E=1.2e-19 PF02518: HATPase_c" amino acids 463 to 580 (118 residues), 89.7 bits, see alignment E=4.5e-29

Best Hits

KEGG orthology group: K14980, two-component system, OmpR family, sensor histidine kinase ChvG [EC: 2.7.13.3] (inferred from 100% identity to rpt:Rpal_0360)

Predicted SEED Role

"Sensor histidine kinase ChvG (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (581 amino acids)

>TX73_001850 sensor histidine kinase (Rhodopseudomonas palustris CGA009)
MRDETPVHGRRWPRPLDWVRRTGQFFFTLSFSSLTRRILSLNLAGLMALSASILYLSQFR
AGLIDARAQSLLVQAEIIAGAIAASATVETNTITIDPDRLLDLKPGESYGPPDEYAVLDF
PINPERVAPVLRRLISPTKTRARIYDRDGVLILDSRSLYGRGDVMRFELPPPTAEKPGIV
ERAMIAIRTWFNRGDLPLYRELGPENGNGYQEVAQSLKGQKSSMVRINDRGEVIVSVSVP
VQRFRAIYGSLMLSTQGDDIDQMVTAERLAILKVFGVAAVVMFVLSVLLASTIAGPVRRL
ADAAERVRRRIRARVEIPDFTRRRDEIGHLSGALRDMTDSLYNRIEAIERFAADVSHELK
NPLTSLRSAVETLPLAKTDNSRARLLSVIEHDVKRLDRLISDISDASRLDAELQRQDAAQ
VDLRRLLTTLTLVANETRLGHNALVEVKFDGPAADQFPVPGHDSRLGQVISNLLSNAQSF
SREGGKVRILCRRRKAEIEIIVEDEGPGIRDDALEKIFERFYTDRPHQGFGQNSGLGLSI
SKQIVEAHGGKIWAENRVGPRGEDGEPTIAGARFIVRLPAT