Protein Info for TX73_001800 in Rhodopseudomonas palustris CGA009

Annotation: bifunctional isocitrate dehydrogenase kinase/phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 610 PF20423: AceK_regulatory" amino acids 49 to 352 (304 residues), 236.6 bits, see alignment E=3.8e-74 PF06315: AceK_kinase" amino acids 354 to 603 (250 residues), 246.7 bits, see alignment E=2.8e-77

Best Hits

Swiss-Prot: 100% identical to ACEK_RHOPA: Isocitrate dehydrogenase kinase/phosphatase (aceK) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K00906, isocitrate dehydrogenase kinase/phosphatase [EC: 2.7.11.5 3.1.3.-] (inferred from 100% identity to rpa:RPA0347)

Predicted SEED Role

"Isocitrate dehydrogenase phosphatase (EC 2.7.11.5)/kinase (EC 3.1.3.-)" (EC 2.7.11.5, EC 3.1.3.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.-

Use Curated BLAST to search for 2.7.11.5 or 3.1.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (610 amino acids)

>TX73_001800 bifunctional isocitrate dehydrogenase kinase/phosphatase (Rhodopseudomonas palustris CGA009)
MTATASHTRARPLGASEIEHATRIAEPDFDLLDALYRTDDPDDQARLLARVVLSAFDNYY
AVSRRIPALAQAAFEARDWPVTVRLSKIRIGLYTACIDQLVPLLKAGLPELTTDEQLWPT
AEAELLAAIEGRYEADFAFAFWQSLRRKLVSDEWRPVSYDAGSTARRTTSPAAVLKTTAT
TLPITAEVIAGILDEAGFRVPWRDRDGDAALAAQAIETALEPLSPRPGEPVKIEIADSGF
LRNRGACLVGRIKLRDRGDMPMRNLPLLIALLNEKDGLVVDAVLTDSDELQYAFSSTLAN
YHATNPRYHELARLLYELMPKRPLGTQYSCIGFHHLGKVAVMSEILAEHRKTKEKLATAP
GFKGTVAIAFTMPSSAYVLKIIRDHPTDDYKFDYFDGLDEVLRKYNLVHEIDRAGSMLDN
IIYSNVKLDRAMFAPELLDELLEAGIGTVTLDRGALVFRHLIVQIKLTPLPLYLANASAA
ESRAAVINLGDCIKNNAAADIFNKDLDGRNYGVSRIRKVYLFDYDAVEPLTSVTVSRDGA
APGEFDNGMVFRPQEMLEGLRIDDPGLRRAFRDAHPELMQADYWEGMQQALRDGKVPKVM
NYPASRRLRR