Protein Info for TX73_001720 in Rhodopseudomonas palustris CGA009

Annotation: nucleotide exchange factor GrpE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 207 PF01025: GrpE" amino acids 36 to 189 (154 residues), 173.6 bits, see alignment E=1.4e-55

Best Hits

Swiss-Prot: 100% identical to GRPE_RHOPA: Protein GrpE (grpE) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

KEGG orthology group: K03687, molecular chaperone GrpE (inferred from 99% identity to rpt:Rpal_0334)

MetaCyc: 37% identical to nucleotide exchange factor GrpE (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Heat shock protein GrpE" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (207 amino acids)

>TX73_001720 nucleotide exchange factor GrpE (Rhodopseudomonas palustris CGA009)
MTETDGQKDNNQDTAQAAADPVVSKPYIMPDDPEEGSNEALVREAADARDKMLRTLAEME
NLRKRTQKEVADARTYGVTSFARDVLDIADNLQRALDAVPADARANAEPGLKALIEGVEL
TERSLLNALEKNGVKKFDPKGQKFDPNFQQAMYEVPDPSVPAGTVVQVVQAGFTIGDRVL
RPALVGVAKGGAKAAPSDGGGETGNLN