Protein Info for TX73_000045 in Rhodopseudomonas palustris CGA009

Annotation: circadian clock protein KaiC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 563 PF06745: ATPase" amino acids 10 to 233 (224 residues), 225.5 bits, see alignment E=1.5e-70 amino acids 249 to 464 (216 residues), 114.2 bits, see alignment E=1.6e-36 PF13481: AAA_25" amino acids 265 to 372 (108 residues), 35.4 bits, see alignment E=2.2e-12

Best Hits

Swiss-Prot: 56% identical to KACL1_SYNY3: KaiC-like protein 1 (sll1595) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K08482, circadian clock protein KaiC (inferred from 100% identity to rpa:RPA0009)

Predicted SEED Role

"Circadian clock protein KaiC" in subsystem Cyanobacterial Circadian Clock

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (563 amino acids)

>TX73_000045 circadian clock protein KaiC (Rhodopseudomonas palustris CGA009)
MADGISKSLTGIEGFDDLTLGGLPSGRPSLVCGSAGCGKTLFASTFLINGARLYDEPGVF
VTFEERPVDIVDNVASLGFDLQGLIAQERVLIEHIAIDPTEVAEVGDYDLEALFLRLEFA
VDQIGAKRIVLDTIESLFSAFQNPAVLRAEIRRLFDWLKQKGLTAVITGERGDGTLTRQG
LEEYVSDCVILLDHRVDNQISTRRLRIVKYRGTAHGTNEYPFLIDEEGFSVLPVSSLGLS
HKVHEERISSGVPDLDAMLSGGGFYRGTSVLITGVAGSGKSSLACMMVDAACRRGEKALY
LSFEESEAQTVRNMKSVGTDLGRWLSTGQLRYIGARPTFYSLEMHLAVMLREVARFKPDL
VVLDPISAFTESGQIGEVQSMLLRIVDYLKSNGITGAFTHLAHGAQTETDAGLSSLMDAW
ILLLNREAHGEFNRELYLLKARGIAHSNQVREFVMSDDGIHLLPPYLGEGGALTGSARRA
EEAKERRAESERRTEVARLQDQIEQRRRRALAQIEALKADLAVDEAELQRLTQAEASFRA
QSERDVTEMARRRGFIGSADDTD