Protein Info for TX73_000035 in Rhodopseudomonas palustris CGA009

Annotation: HWE histidine kinase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 482 TIGR00229: PAS domain S-box protein" amino acids 53 to 167 (115 residues), 29.9 bits, see alignment E=2.6e-11 PF00989: PAS" amino acids 54 to 146 (93 residues), 23.3 bits, see alignment E=1.9e-08 PF08448: PAS_4" amino acids 61 to 163 (103 residues), 42.6 bits, see alignment E=2.3e-14 PF07568: HisKA_2" amino acids 301 to 362 (62 residues), 30.3 bits, see alignment E=1.3e-10 PF07536: HWE_HK" amino acids 301 to 381 (81 residues), 84 bits, see alignment E=3.6e-27

Best Hits

KEGG orthology group: None (inferred from 99% identity to rpt:Rpal_0007)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (482 amino acids)

>TX73_000035 HWE histidine kinase domain-containing protein (Rhodopseudomonas palustris CGA009)
MSAVSALSRAELEARLEEAEETLRAIRDGEIDAVVVRAADEEQVFTLEGGGQSYRTFMET
MDVGAAAFDQDGQLLYANQALCALLDCAHGSLTASALIALLDPANQAAFRRLLAQAQRER
QSAEIHLRVGDAERSMLLTGTPLEFGVVHGAAITFTDISEREQAAAARESERLARAILAS
ANEAVIVCDRAGRVTHLNGAAMRICAEAPVGKTFAEAIALSFPEASELMSSDDIVTMATA
GLPVQGLEAAVRIPSAAITDVMISAAPLVVSGERTQGCVVTLVDLSQRKAAERHQALLMG
ELDHRVKNTLTMVMAICARTAAHERTIEDFQKSFTGRIQALAATHTLLSNASWQNLHIRD
VLAAELAPFASLSSGRIVTDGLDIAVDAKTAVSLGLVFHELTTNAVKYGALSVPSGRISV
RRVGATDEALTIEWQEHDGPPVTPPQSSGFGQTLISRSLGNGGAKLEFDSAGVVCRISIP
RS