Protein Info for Synpcc7942_2515 in Synechococcus elongatus PCC 7942

Annotation: putative DNA helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 755 signal peptide" amino acids 1 to 53 (53 residues), see Phobius details PF00580: UvrD-helicase" amino acids 22 to 323 (302 residues), 103.7 bits, see alignment E=2.9e-33 PF13245: AAA_19" amino acids 27 to 306 (280 residues), 44.5 bits, see alignment E=3.4e-15 PF13361: UvrD_C" amino acids 588 to 722 (135 residues), 62.5 bits, see alignment E=9.7e-21

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to syc:syc1591_d)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA/Rep, cyanobacterial paralog" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31K74 at UniProt or InterPro

Protein Sequence (755 amino acids)

>Synpcc7942_2515 putative DNA helicase (Synechococcus elongatus PCC 7942)
MIATPSLADRLQKMRAQLRAGQQQLAAWQAGSLAVSAVPGAGKSTGMAVAAAIALAQRPQ
RDRRQLYLVTVTRSAALNLRQKVRETLQQLGLSAVGFTVQTLHSLSLQIASTAPDLSNLY
WDQVSLVSDRRKAQLLRQAIDQWIEANPTLFQQLLRGTGFDGELAEQLRRSSVLRNEFLF
ELAKTLIPEIKSSGLSPADFADRLSPWPVLGDYPLLVIAQGLYEFYQVGLQQASLIDFDD
MVLSAVRVLDNPQARRTWQSSILALFEDEAQDSSPLQMQLLERLAPVTTDQQLQLVRVGD
PNQAINSTFTSADPLFFRQFCEQCDRRQQLVMFDQAGRSSPTIFRAANFVLQWVNRHWAH
SDSLRPFREQAIQPVDAEDPQLNANPEPLGLGLELLQTETTIATVERLQQRLIDLYAANA
ETQAAILVRENRQAHYLRDRLTEPLAKAGIHLWEASDRDRNRRIPEEMLALLQFIERPHQ
PDRLRAALQVLVNRDRLPALPWEALPAPEIFLGDRLFWPDANPRLLPAQRLCQQLLKARS
ELPPEQLIPFLALTLHYDGSELATADQLADQLGRQAWSNLSLGQLLADLQNLLESDRLTS
VETEDPGLALTRSGQVTILTMHRSKGLDWDCVFLPFLEASQIPGGRSPKQSEAFLGPQPW
IAIARLQLRRALQAETGAGVEPFTDLAAAVSEAQALREAEEYRLLYVAMTRAKRLLWMAS
AQQAPRNWTFPQSLIDQTPCPALAALYRQFPQHRC