Protein Info for Synpcc7942_2305 in Synechococcus elongatus PCC 7942

Name: nblR
Annotation: two component transcriptional regulator, winged helix family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 PF00072: Response_reg" amino acids 9 to 118 (110 residues), 65 bits, see alignment E=6.7e-22 PF00486: Trans_reg_C" amino acids 150 to 225 (76 residues), 98.1 bits, see alignment E=2.6e-32

Best Hits

Swiss-Prot: 46% identical to MPRA_MYCLE: Response regulator MprA (mprA) from Mycobacterium leprae (strain TN)

KEGG orthology group: K11332, two-component system, OmpR family, response regulator NblR (inferred from 100% identity to syc:syc1796_c)

Predicted SEED Role

"Two-component response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See O68523 at UniProt or InterPro

Protein Sequence (228 amino acids)

>Synpcc7942_2305 two component transcriptional regulator, winged helix family (Synechococcus elongatus PCC 7942)
MIAPASPHILLIESDSSLAQQMAGDLLQAGYGTSLANVQQDLFAQIDLQKPDLVIVDRMA
GGQSGLQFCRQLRDRGLTIPILLLMGRDTVEDRVACLEAGADDYLLKPYRSDEFLRRLQL
YLQREPAAQEHLQFSNLTLDLSTRRAARNGRQIDLTMKEFDLLRFLMEHPREVLTREQIL
ENVWGYDFMGESNVIEVYIRYLRLKIEIEGEKRLVQTVRGVGYVLRES