Protein Info for Synpcc7942_2199 in Synechococcus elongatus PCC 7942

Name: dnaE
Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 870 TIGR00594: DNA polymerase III, alpha subunit" amino acids 3 to 759 (757 residues), 1098 bits, see alignment E=0 PF02811: PHP" amino acids 6 to 180 (175 residues), 171.9 bits, see alignment E=2.2e-54 PF07733: DNA_pol3_alpha" amino acids 304 to 570 (267 residues), 330.4 bits, see alignment E=1.4e-102 PF17657: DNA_pol3_finger" amino acids 573 to 738 (166 residues), 228.3 bits, see alignment E=5.2e-72 TIGR01445: intein N-terminal splicing region" amino acids 758 to 833 (76 residues), 46.3 bits, see alignment E=6.5e-16

Best Hits

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 100% identity to syc:syc1898_d)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7) / Carboxy-terminal intein-mediated trans-splice" in subsystem Inteins or DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31L40 at UniProt or InterPro

Protein Sequence (870 amino acids)

>Synpcc7942_2199 DNA polymerase III subunit alpha (Synechococcus elongatus PCC 7942)
MSFVGLHMHSDYSLLDGASQLPDLVARAKELGMPAIALTDHGVMYGAIELLKVCKNQGNI
RPIIGNEMYVINSPIDDPNPRVRKYHQIVLAKNKKGYQNLVKLTSISHLQGFKGRGIFAR
PCIDKEHLEKYREGLIVTSACLGGEIPQAILQSRPDVARRVAAWYQERFGEDFYLEIQDH
GSPEDRIVNVEIVRIAQELGIELVATNDSHFISCFDVEAHDALLCIQTGKLVVEDKRLRY
SGTEYLKSAEEMHQLFRDHLPDDVIAKAIANTLVIASKIEDYNILGEPKIPTFPVPDGYN
EETYMAEVARQGLAERLNCDRYEDCEEAYRDRLEYEIKMMHEMGFASYFLVVWDYIKFAR
DNNIPVGPGRGSAAGSLVAYCMGITNIDPVHHGLLFERFLNPERKSMPDIDTDFCIDQRD
KVIDYVTKKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADRMAKLIPVARGKPAK
LKVMISDQTPAPEFKEKYEKDARVKHWVDMALRIEGTNKTFGVHAAGVVISAVPLDEIVP
LQRNNDGQVITQYYMEDIEACGLLKMDFLGLRNLTMIQKAIDLVQETSGQAIDPDRLPMD
DPKTYQLLAKGDLEGVFQLESSGMRQIVRDLKPSNLEDISSILALYRPGPLDAGLIPKFI
NRKHGREAIDYADQMLQPILNETYGIMVYQEQIMKIAQDMGGYTLGEADLLRRAMGKKKM
SEMVKHQSTFVEGAKKNGVAEKVAAELFDQMVLFAEYCLAADTEVLTVEYGPIAIGKLVE
ENIRCQVYCCNPDGYIYSQPIGQWHQRGEQEVIEYELSDGRIIRATADHRFMTEEGEMLS
LDEIFERSLELKQIPTPLLAIAQPSPLATA