Protein Info for Synpcc7942_1379 in Synechococcus elongatus PCC 7942

Name: accC
Annotation: acetyl-CoA carboxylase biotin carboxylase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00514: acetyl-CoA carboxylase, biotin carboxylase subunit
  • amino acids 3 to 445 (443 residues), 800.5 bits, E=2.2e-245
• PF00289: Biotin_carb_N
  • amino acids 3 to 111 (109 residues), 152.4 bits, E=1.5e-48
• PF02786: CPSase_L_D2
  • amino acids 116 to 323 (208 residues), 283.8 bits, E=1.9e-88
• PF02222: ATP-grasp
  • amino acids 139 to 293 (155 residues), 43.1 bits, E=9.7e-15
• PF07478: Dala_Dala_lig_C
  • amino acids 143 to 292 (150 residues), 35.3 bits, E=2.3e-12
• PF02785: Biotin_carb_C
  • amino acids 337 to 444 (108 residues), 138.7 bits, E=1.9e-44

Best Hits

Swiss-Prot: 78% identical to ACCC_NOSS1: Biotin carboxylase (accC) from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

KEGG orthology group: K01961, acetyl-CoA carboxylase, biotin carboxylase subunit [EC: 6.3.4.14 6.4.1.2] (inferred from 100% identity to syf:Synpcc7942_1379)

MetaCyc: 68% identical to biotin carboxylase (Arabidopsis thaliana col)
Biotin carboxylase. [EC: 6.3.4.14]

Predicted SEED Role

"Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.3.4.14)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• jadomycin biosynthesis (3/9 steps found)
• 3-hydroxypropanoate cycle (4/13 steps found)
• glyoxylate assimilation (3/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (4/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (4/18 steps found)
• superpathway of mycolate biosynthesis (15/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14, 6.4.1.2

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.2

Sequence Analysis Tools

See Q54755 at UniProt or InterPro

Protein Sequence (453 amino acids)

>Synpcc7942_1379 acetyl-CoA carboxylase biotin carboxylase subunit (Synechococcus elongatus PCC 7942)
MRFNKILIANRGEIALRILRTCEELGIGTIAVHSTVDRNALHVQLADEAVCIGEAASSKS
YLNIPNIIAAALTRNASAIHPGYGFLAENARFAEICADHHLTFIGPSPDSIRAMGDKSTA
KETMQRVGVPTIPGSDGLLTDVDSAAKVAAEIGYPVMIKATAGGGGRGMRLVREPADLEK
LFLAAQGEAEAAFGNPGLYLEKFIDRPRHVEFQILADAYGNVVHLGERDCSIQRRHQKLL
EEAPSPALSADLRQKMGDAAVKVAQAIGYIGAGTVEFLVDATGNFYFMEMNTRIQVEHPV
TEMITGLDLIAEQIRIAQGEALRFRQADIQLRGHAIECRINAEDPEYNFRPNPGRITGYL
PPGGPGVRVDSHVYTDYEIPPYYDSLIGKLIVWGATREEAIARMQRALRECAITGLPTTL
SFHQLMLQMPEFLRGELYTNFVEQVMLPRILKS