Protein Info for Synpcc7942_0942 in Synechococcus elongatus PCC 7942

Name: ftsH
Annotation: FtsH peptidase homologue, chloroplast. Metallo peptidase. MEROPS family M41

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 630 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 118 to 140 (23 residues), see Phobius details PF06480: FtsH_ext" amino acids 9 to 113 (105 residues), 37.7 bits, see alignment E=6.2e-13 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 120 to 613 (494 residues), 757 bits, see alignment E=4.6e-232 PF06068: TIP49" amino acids 208 to 244 (37 residues), 24.7 bits, see alignment 4e-09 PF07728: AAA_5" amino acids 209 to 329 (121 residues), 24.3 bits, see alignment E=8.1e-09 PF00004: AAA" amino acids 210 to 341 (132 residues), 160.8 bits, see alignment E=7.3e-51 PF17862: AAA_lid_3" amino acids 365 to 408 (44 residues), 45.7 bits, see alignment 1.1e-15 PF01434: Peptidase_M41" amino acids 424 to 612 (189 residues), 236 bits, see alignment E=9.6e-74

Best Hits

Swiss-Prot: 79% identical to FTSH2_SYNY3: ATP-dependent zinc metalloprotease FtsH 2 (ftsH2) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 100% identity to syc:syc0600_d)

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31PP7 at UniProt or InterPro

Protein Sequence (630 amino acids)

>Synpcc7942_0942 FtsH peptidase homologue, chloroplast. Metallo peptidase. MEROPS family M41 (Synechococcus elongatus PCC 7942)
MKWNWRTLALWTLPILVIGFFVWQGGIGANLQTNSTINAASTRMTYGRFLEYLDAGRVTA
VDFYEGGRTAIVEAVDPDLDNRLQRLRVDLPGTSPDLITRLRDSDINFDVHPPRNDGAIW
GLLSNLIFPILLIVGLFFLFRRSGNVPGGPGQAMQFGKSKARFQMDAKTGVLFDDVAGIE
EAKEELQEVVTFLKNSERFTAVGARIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSISG
SEFVEMFVGVGASRVRDLFKKAKENAPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQL
LTEMDGFEGNTGIIIIAATNRPDVLDAALTRPGRFDRQIIVDAPDIKGRLEILKVHARNK
KLAEDVSLDVIARRTPGFAGADLANLLNEAAILTARRRKDAITLTEIDDAVDRVVAGMEG
TPLVDGKSKRLIAYHEVGHAIVGTLVKDHDPVQKVTLIPRGQAQGLTWFAPDEEQGLTSR
AQILARIKGALGGRAAEDVIFGHDEVTTGAGNDLQQVTGMARQMVTRFGMSDLGPLSLEG
QSQEVFLGRDLMTRSEYSERIAIRIDAQVHDIVDHCYQETLQLIRDNRIVIDRLVDLLIE
KETIDGDEFRQIVAEYCQVPEKERFVPQLI