Protein Info for Synpcc7942_0660 in Synechococcus elongatus PCC 7942

Name: tyrA
Annotation: arogenate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 45 to 63 (19 residues), see Phobius details PF03807: F420_oxidored" amino acids 47 to 132 (86 residues), 29.7 bits, see alignment E=1.6e-10 PF03446: NAD_binding_2" amino acids 47 to 139 (93 residues), 27.9 bits, see alignment E=4.5e-10 PF02153: PDH_N" amino acids 65 to 207 (143 residues), 127.3 bits, see alignment E=7.7e-41 PF20463: PDH_C" amino acids 211 to 314 (104 residues), 83.4 bits, see alignment E=2.6e-27

Best Hits

KEGG orthology group: K15226, arogenate dehydrogenase (NADP+) [EC: 1.3.1.78] (inferred from 100% identity to syf:Synpcc7942_0660)

MetaCyc: 51% identical to arogenate dehydrogenase monomer (Synechocystis sp. PCC 6803)
Arogenate dehydrogenase (NADP(+)). [EC: 1.3.1.78]

Predicted SEED Role

"Arogenate dehydrogenase (EC 1.3.1.43)" in subsystem Chorismate Synthesis or Phenylalanine and Tyrosine Branches from Chorismate (EC 1.3.1.43)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.43 or 1.3.1.78

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31QH7 at UniProt or InterPro

Protein Sequence (323 amino acids)

>Synpcc7942_0660 arogenate dehydrogenase (Synechococcus elongatus PCC 7942)
MMRPGIFCSLLSQPAAQQLVNFDLKHWLILAASGSVGSTTVARDVMRIGIVGLGLIGGSL
GFDWRDRGHRLLGYSRRPATCERAIARGVVDHASPDPAVLTEAEVIVLATPLGVLETTVR
ELRDYWHPEAIVTDVGSVKQPIVAALDPLWPRFVGGHPMAGTAENGIEAALRGLFQNRPY
VLTPTDQTDPAAIAVVAQLAQELGSVVLHCDPASHDRAVATISHLPVFISASLIQTCLQE
PDPAVQTLAATLASSGFCDTSRVGGGNPELGVMMARYNQAALLEQIDRYQIQLERLKTAI
AAADEPAIAAILQQNQEMRPRYL