Protein Info for Synpcc7942_0487 in Synechococcus elongatus PCC 7942

Name: lepB
Annotation: thylakoidal processing peptidase. Serine peptidase. MEROPS family S26A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 220 PF10502: Peptidase_S26" amino acids 26 to 184 (159 residues), 179.2 bits, see alignment E=3.3e-57 TIGR02227: signal peptidase I" amino acids 30 to 187 (158 residues), 164.9 bits, see alignment E=7.1e-53

Best Hits

Swiss-Prot: 63% identical to LEP_PHOLA: Signal peptidase I (lepB) from Phormidium laminosum

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 100% identity to syf:Synpcc7942_0487)

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.89

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31R00 at UniProt or InterPro

Protein Sequence (220 amino acids)

>Synpcc7942_0487 thylakoidal processing peptidase. Serine peptidase. MEROPS family S26A (Synechococcus elongatus PCC 7942)
MAKPETSSTSTASSDTPSPKKENVWLENAKTLGLSIIFALGIRQFVAEARYIPSGSMLPT
LQINDRLIIDKVSYRFNPPQRGDIIVFEPPFALRKRGYDDAFIKRVIGLPGDTVEVRDGQ
VYVNGKVLNENYIAQEPSYTWGPKTVPANSYLVLGDNRNNSYDSHYWGFVPENKIIGKAL
VRFWPLNRLGEVEPLPSYQKTPPITPLGWRLPHPTHQRLS