Protein Info for Synpcc7942_0194 in Synechococcus elongatus PCC 7942

Name: polA
Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 953 TIGR00593: DNA polymerase I" amino acids 8 to 953 (946 residues), 993.9 bits, see alignment E=4.6e-303 PF02739: 5_3_exonuc_N" amino acids 8 to 186 (179 residues), 163.2 bits, see alignment E=9.1e-52 PF01367: 5_3_exonuc" amino acids 187 to 281 (95 residues), 114.5 bits, see alignment E=5.4e-37 PF01612: DNA_pol_A_exo1" amino acids 343 to 522 (180 residues), 100.1 bits, see alignment E=2.6e-32 PF00476: DNA_pol_A" amino acids 562 to 951 (390 residues), 489.6 bits, see alignment E=1.3e-150

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 100% identity to syc:syc1317_d)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q31RU3 at UniProt or InterPro

Protein Sequence (953 amino acids)

>Synpcc7942_0194 DNA polymerase I (Synechococcus elongatus PCC 7942)
MSVDSPLLLLVDGHSLAFRSYYAFAKGRDGGLRTRTGIPTSVCFGFLKALLEVMEQQQPK
ALAIAFDLGGPTFRHEADENYKANRDEAPEDFKIDTDNLVALLQTLNLPILVEPGYEADD
LLGTVAQRGAEAGYRVRILSGDRDLFQLVDPEGAIRVLYLGNTFGRSANREAAREIDPAA
VIDKLGVPPEQVIDFKALCGDSSDNIPGVKGIGPKTAVDLLQAWGDLDRIYDNLEAIKPA
VRKKLESDREAAYHSRKLAQIVTDIPLAIDWDHYALTGFDEQEVLPWLEKLELQAFRRQV
DRLQQLFGGQPPTVEALSDESLDFWTAEETAAQQPRWPQLQPQIITTAAALTDLVTLLEQ
RDSPEAIVAWDTETTDLDPRLAQLVGIGCAWGEEPDQLAYIPLGHEEGEQLPLQTVLTAL
RPILESDRHPKALQNAKFDRLILRHQGIELAGVVFDTMLASYLLNPSLGHSLDALADRWL
KLQTRSYSDLVPKGKTIAQVAIAAVAQYCGSDVHVVQRLIPLLKAGIAESPALQFLLETV
ELPLEAVLAEMEDRGIRIDEGYLAELSEHLKGELDRLEGAAHTLAGDRFNLGSPKQLSEL
LFEKLGLNVKKSRKTKTGYSTDAAVLEKLQGDHPIIDLILEHRTLAKLKSTYVDALPSLV
AADGRIHTDFNQAVTATGRLSSSNPNLQNIPIRTEFSRQIRKAFLPREGWLLAAADYSQI
ELRILAHLSQEPVLLEAYRQGDDVHRLTASLLFDREEITSEERRIGKIINFGVIYGMGAQ
RFARETGSSTKEAQGFIDRFYDRYPRVFTYLQSLERQAIARGYVETVLGRRRYFDFEDTG
LQKLRGSDPESIDLDKIRPSRFEAQLLRAAANAPIQGSSADIIKVAMVQLQALLQSYQAR
MLLQVHDELVLELPPEEWDSLAPQIQQTMEQAVQLTVPLAVELHAGHNWMEAK