Protein Info for Synpcc7942_0039 in Synechococcus elongatus PCC 7942

Name: gnd
Annotation: 6-phosphogluconate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 471 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR00873: 6-phosphogluconate dehydrogenase (decarboxylating)" amino acids 5 to 470 (466 residues), 717.1 bits, see alignment E=4.9e-220 PF03446: NAD_binding_2" amino acids 5 to 174 (170 residues), 166.9 bits, see alignment E=3.8e-53 PF00393: 6PGD" amino acids 179 to 470 (292 residues), 433.1 bits, see alignment E=5.4e-134

Best Hits

Swiss-Prot: 100% identical to 6PGD_SYNE7: 6-phosphogluconate dehydrogenase, decarboxylating (gnd) from Synechococcus elongatus (strain PCC 7942)

KEGG orthology group: K00033, 6-phosphogluconate dehydrogenase [EC: 1.1.1.44] (inferred from 100% identity to syc:syc1460_c)

MetaCyc: 60% identical to 6-phosphogluconate dehydrogenase (decarboxylating) (Bacillus subtilis)
Phosphogluconate dehydrogenase (decarboxylating). [EC: 1.1.1.44]

Predicted SEED Role

"6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)" in subsystem Pentose phosphate pathway (EC 1.1.1.44)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.44

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P21577 at UniProt or InterPro

Protein Sequence (471 amino acids)

>Synpcc7942_0039 6-phosphogluconate dehydrogenase (Synechococcus elongatus PCC 7942)
MALQQFGLIGLAVMGENLALNIERNGFSLTVYNRTAEKTEAFMADRAQGKNIVPAYSLED
FVASLERPRRILVMVKAGGPVDAVVEQLKPLLDPGDLIIDGGNSLFTDTERRVKDLEALG
LGFMGMGVSGGEEGALNGPSLMPGGTQAAYEAVEPIVRSIAAQVDDGPCVTYIGPGGSGH
YVKMVHNGIEYGDMQLIAEAYDLLKSVAGLNASELHDVFAAWNKTPELDSFLIEITADIF
TKVDDLGTGQPLVELILDAAGQKGTGRWTVETALEIGVAIPTIIAAVNARILSSIKAERQ
AASEILSGPITEPFSGDRQAFIDSVRDALYCSKICSYAQGMALLAKASQVYNYGLNLGEL
ARIWKGGCIIRAGFLNKIKQAYDADPTLANLLLAPEFRQTILDRQLAWRRVIAIAAERGI
PVPAFSASLDYFDSYRRDRLPQNLTQAQRDYFGAHTYERTDRSGSFHAQWF