Protein Info for Synpcc7942_0003 in Synechococcus elongatus PCC 7942

Name: purL
Annotation: phosphoribosylformylglycinamidine synthase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 777 PF18072: FGAR-AT_linker" amino acids 18 to 54 (37 residues), 52 bits, see alignment 1.2e-17 TIGR01736: phosphoribosylformylglycinamidine synthase II" amino acids 20 to 772 (753 residues), 890.6 bits, see alignment E=4.1e-272 PF00586: AIRS" amino acids 75 to 190 (116 residues), 101.5 bits, see alignment E=5.8e-33 amino acids 452 to 583 (132 residues), 89.5 bits, see alignment E=3.1e-29 PF02769: AIRS_C" amino acids 203 to 357 (155 residues), 131 bits, see alignment E=6.9e-42 amino acids 597 to 742 (146 residues), 61.9 bits, see alignment E=1.3e-20

Best Hits

Swiss-Prot: 100% identical to PURL_SYNE7: Phosphoribosylformylglycinamidine synthase subunit PurL (purL) from Synechococcus elongatus (strain PCC 7942)

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 100% identity to syf:Synpcc7942_0003)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q55041 at UniProt or InterPro

Protein Sequence (777 amino acids)

>Synpcc7942_0003 phosphoribosylformylglycinamidine synthase II (Synechococcus elongatus PCC 7942)
MTAISSAPFSADEIAGEGIKPEEYDAIVERLGRHPNKAELGMFGVMWSEHCCYKNSRPLL
SQFPTEGLRILVGPGENAGVVDLGDGLHLAFKVESHNHPSAVEPFQGAATGVGGILRDIF
TMGARPIAILNSLRFGDLEQPRTRRLFHGVVSGISHYGNCVGVPTVGGEVAFDPAYNGNP
LVNAMALGLMETDEIVKAGASGIGNPVLYVGSTTGRDGMGGASFASAELSDESLDDRPAV
QVGDPFLEKSLIEACLEAFKTGAVVAAQDMGAAGLTCSTAEMAAKGGVGVELDLDLIPVR
ESGMVPYEYLLSESQERMLFVAAAGREQELIDIFHRWGLQAVVAGKIIAEPIVRIFWQGA
IAAEIPATALSDNTPIYHRQLPDEPPAYAQQAWQWTIDQLPAATEVGCGDRSWNDLLLTL
LDSPTIASKRWVYRQYDHQVQNNTVVLPGAADAAVVRLRPQMGAAALKTSNKGVAATTDC
NARYCYLQPYEGAKAAVAEAARNLSCVGAEPLAVTDNLNFGSPEKPIGYWQLAEACRGLS
EACREFSTPVTGGNVSLYNETLDSDGKPQPIYPTPVVGMVGLVPNLDRVCGQGFQSVGDR
LYLLGLPTQAADDRLSLGGSEYLAIAHQTVAGLPPRIDFDLERRVQAVCRLGIHQGWIRS
AHDSAEGGLAVAIAESAIAGSLGARVNLGELVGHRPDWLLFAEGGARILVSVDPAHVAVW
EAELQAQIPAAWQAIGTVTEADAGLAIAAGNQPLVQLSVDQLQQTWGGAIERRLAKD