Protein Info for SMc04403 in Sinorhizobium meliloti 1021

Annotation: peptidyl-dipeptidase A protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 687 PF01432: Peptidase_M3" amino acids 233 to 684 (452 residues), 415.1 bits, see alignment E=2.8e-128

Best Hits

Swiss-Prot: 42% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 100% identity to sme:SMc04403)

MetaCyc: 42% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92KZ0 at UniProt or InterPro

Protein Sequence (687 amino acids)

>SMc04403 peptidyl-dipeptidase A protein (Sinorhizobium meliloti 1021)
MTTIASLNPALVHWTGHEGLPRFEAIMDEDFAPAFDAALASHEAEIEAIADNPEDPTFAN
TVVALEIAGDELSRVSALFWSKAGAHTNEVIQALEREIAPKMSRHYSKIGTNPALFGRID
ALWEKREELGLDVEAMRVLERHWKSFVKAGAKLHKPEQERLAAINEKLAGLGARFGQNVL
ADEKDWALILSGEEDLAGIPDFLRDAMAAAARERGEEDKYAVTLSRSIIEPFLTFSERRE
LREQAFRAWTARGENGGETDNRGIIAETLALRAEKAKLLGYENYAALKLDNTMAKTPEAV
NGLLMQVWEKAVARAREEEADLATLIAEEGRNHEVMPWDWRHYAEKFRAQKFSFSESELK
PYLQLEKIIDACFAVARRLFGITATEKKGIPAYHPDVRVFEIRDASGRLTALFLGEYFAR
SSKRSGAWMSSFQSQHRLKLKNGETGEIPIVYNVCNFAKPAEGKPALLSIDDARTLFHEF
GHALHGMLSNVTYPSVSGTGVARDFVELPSQLYEHWLTVPDILRKYAVHYRTGEPMPQAL
LDKVLAARTFNSGFATVEFTASALVDMAYHTAEAVGDPMALEAATLEKIGLPQSIVMRHR
SPHFLHVFSGDGYSAGYYSYMWSEVLDADAFAAFEETGDPFDPAMAARLKDNIYSVGGSL
DPEDAYKAFRGKLPSPDAMLAKKGLAA