Protein Info for SMc04399 in Sinorhizobium meliloti 1021
Annotation: acyl-COA transferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to smk:Sinme_3296)Predicted SEED Role
"Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8) / Acetyl-CoA:acetoacetyl-CoA transferase, beta subunit (EC 2.8.3.8)" in subsystem Acetyl-CoA fermentation to Butyrate (EC 2.8.3.8)
MetaCyc Pathways
- acetyl-CoA fermentation to butanoate (6/7 steps found)
- acetoacetate degradation (to acetyl CoA) (2/2 steps found)
- L-glutamate degradation V (via hydroxyglutarate) (6/10 steps found)
- pyruvate fermentation to acetone (2/5 steps found)
- 4-aminobutanoate degradation V (3/7 steps found)
- L-glutamate degradation XI (reductive Stickland reaction) (3/7 steps found)
- gallate degradation III (anaerobic) (5/11 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
- succinate fermentation to butanoate (1/7 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.8.3.8
Use Curated BLAST to search for 2.8.3.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92KZ4 at UniProt or InterPro
Protein Sequence (540 amino acids)
>SMc04399 acyl-COA transferase (Sinorhizobium meliloti 1021) MRMTGKHISLADAAGLIPDGAVVSVSSSSGLGCPDLMLKAIGERFEATGHPRDLTTLHPI AAGDMSGIKGVDYIARKGLLKKIIGGSYPSGPSSAEPPLIWQMIGANEVAAYNIPSGILF DMHREAAAKRPGVMTKVGLDTFVDPSREGCAMNASAAAEPVVKKVAFEGEDWLYFKAIAP QVAIIRATTADERGNLTYEHEGAYLGGLDQALAARNNGGIVIAQVKRIAKEGSLKPHDVR VPGVLVDYVVVDPDQKQTTQTLYDPAISGEIFRPLDSFRLPEFNIQKAIARRVAQELEAG SAVNLGFGISANVPRILIEEGLHGAVTWVIEQGAVGGVPLLDFAFGCASNADAFMPSPYQ FTYFQGAGFDASLLSFLEIDRTGSVNVSKLSFRPHVTAGAGGFVDITARAKKIVFSGMFN AGAKLAVADGRLVIEKEGKLRKLVNAVEHVTFSGRRAVEQGQDITYVTERCVMKLTPEGV MLTEIAPGVDLETDILGQSEFPLIVSDALKPMDPALFGEGPIGLTLPAKAPRRLKGGADG