Protein Info for SMc04303 in Sinorhizobium meliloti 1021

Annotation: cobaltochelatase subunit CobN

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1275 TIGR02257: cobaltochelatase, CobN subunit" amino acids 1 to 1264 (1264 residues), 1792.7 bits, see alignment E=0 PF02514: CobN-Mg_chel" amino acids 138 to 1252 (1115 residues), 1302.1 bits, see alignment E=0

Best Hits

Swiss-Prot: 84% identical to COBN_SINSX: Aerobic cobaltochelatase subunit CobN (cobN) from Sinorhizobium sp.

MetaCyc: 84% identical to CobN (Pseudomonas denitrificans (nom. rej.))
Cobaltochelatase. [EC: 6.6.1.2]

Predicted SEED Role

"CobN component of cobalt chelatase involved in B12 biosynthesis" in subsystem Coenzyme B12 biosynthesis

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.6.1.2

Use Curated BLAST to search for 6.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92P36 at UniProt or InterPro

Protein Sequence (1275 amino acids)

>SMc04303 cobaltochelatase subunit CobN (Sinorhizobium meliloti 1021)
MHLLLAQKGTIADGNEAIDLGQSPGDILFLSAADTELASIAAAHRQRAGARSLRIASLMN
LMHPMSVDTYVERTARHAKLIVVRPLGGASYFRYVLEALYAAAVANKFQIAVLPGDDKPD
PGLDPFSTVSVEDRQRLWGYCTEGGAENAGLFLDYAQALIDGGDKPQPARPLLKAGIWWP
GRGVIGVEEWVRLSELRRAVPTAQADRAEHEPTVAVCFYRALVQSGETKPVEALIEALAA
EGVRALPVFVSSLKDPVSIGTLEAVFAEALPDVVMNATGFAVSAPGADRQPTVLESGGAP
VLQVIFSGSSREGWETSAQGLMARDLGMNVALPEVDGRVLSRAVSFKAASVYDPLVEANI
VGHEPLTDRARFAARLAANWTKLRRTRPEGRRVAIVMANYPNRDGRLGNGVGLDTPAGTI
EVLKAMTAEGYAVGNVPDDGDALIGFLMAGPTNAASRDREIRETISLNRYKGFFDALPKK
IQEEVTARWGAAEADPFFIDGVFALPLARFGDVLVGIQPARGYNIDPKETYHAPDLVPPH
GYLAFYAYLREVFGAHAIVHMGKHGNLEWLPGKALALSEECYPEVIFGPMPHLYPFIVND
PGEGTQAKRRTSAVIIDHLTPPLTRAESYGPLKDLEALVDEYYEAAGGDPRRLRLLSRQI
LDLVRDIGLDHDAGIEKGDSENRALEKLDAYLCDLKEMQIRDGLHVFGLAPEGRLLTDLT
VALARVPRGLGEGGDQSLQRAIAVDLGLHAASRSQRPQPFDPLDCVMSDPWAGLKPDLLA
ALSDAPWRTAGDTVERIELLAAKLVSGEIACPVGWTNTRAVLAVIETRLKPSIQSSGEAE
IKGLLTGLDGRFVAPGPSGAPTRGRPDVLPTGRNFYSVDSRSVPTPAAYELGKKSAELLI
RRYLQDHGEWPSSFGLTAWGTSNMRTGGDDIAQALALIGAKPVWDMASRRVTGYEIIPLA
VLGRTRVDVTLRISGFFRDAFPEQIALFDKAVRAVGALDEDDADNMIAARMRAETRRWEE
RGADAKEARRRASYRVFGSKPGAYGAGLQALVDEKGWETRGDLAEAYLSWGGYAYGAGED
GKAERGLFEERLRSIEAVVQNQDNREHDLLDSDDYYQFEGGMSAAAEHLGGQRPAIYHND
HSRPEKPVIRSLEEEIGRVVHARVVNPKWIDGVMRHGYKGAFEIAATVDYMFAFAATTGA
VRDHHFEAAYQAYIADEKVLGFLREKNPAALSEISERLLEAIDRGLWNPRSNSARFELNS
LSGRAATDRLMAGNQ