Protein Info for SMc04227 in Sinorhizobium meliloti 1021

Annotation: chemoreceptor methyl-accepting chemotaxis transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 604 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 188 to 213 (26 residues), see Phobius details PF08269: dCache_2" amino acids 38 to 184 (147 residues), 134.9 bits, see alignment E=8.7e-43 PF17200: sCache_2" amino acids 39 to 188 (150 residues), 150.7 bits, see alignment E=8.2e-48 PF17201: Cache_3-Cache_2" amino acids 77 to 182 (106 residues), 39.1 bits, see alignment E=1.4e-13 PF00672: HAMP" amino acids 208 to 259 (52 residues), 43.9 bits, see alignment 6.2e-15 PF00015: MCPsignal" amino acids 402 to 558 (157 residues), 168.1 bits, see alignment E=4.3e-53

Best Hits

KEGG orthology group: K03406, methyl-accepting chemotaxis protein (inferred from 100% identity to sme:SMc04227)

Predicted SEED Role

"Methyl-accepting chemotaxis protein I (serine chemoreceptor protein)" in subsystem Bacterial Chemotaxis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7APD1 at UniProt or InterPro

Protein Sequence (604 amino acids)

>SMc04227 chemoreceptor methyl-accepting chemotaxis transmembrane protein (Sinorhizobium meliloti 1021)
MRRIRISARLYALVAFALLTMAAALTFGLIQAQDKLVAERKAMLAAMNENAITVFDAYHA
QEKAGTLTREEAQGCALEAIRAMRYQDSGYFWVNDMHPKMVMHPIKPELDGADLTQNKDP
NGKFLFVEFVKTVQAHGKGFVDYYWPKPGADEPVLKYSHVAGFEPWGWVVGTGVYADDLA
AMFRERAWQMAGILVAAALAILMAALAIVRSVVRPIEKLKVSMRAIADEDLSSDVPETDR
ADEIGQMAKVLVVLRDSVRERLELRSREAEQQDRLDAERRGHEERQRTTAATQAEAMETL
GAALERLANGDLTAAVARIAPEYAKLKDDFNTAVAALRDVIGAISRSTEIVHGSAADISE
AANNLSRRTEQQAAALEETAAALDEITSTVRHASGRALEARDMVDETKASAAKSGDIVRN
AIDAMGRIEASSSRISQIIGVIDEIAFQTNLLALNAGVEAARAGEAGRGFAVVAQEVREL
AQRSAGAAKEIKALIGTSVKEVGAGVELVRSTGDALMEIDALVNRVNEQVAAIATAAREQ
ATGLQEVNTAVNSMDQMTQQNAAMVEETTAASQTLAQESRELKALLEQFRLEERGAQPAY
GRAA