Protein Info for SMc04091 in Sinorhizobium meliloti 1021

Annotation: heat shock protein HtpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 transmembrane" amino acids 7 to 24 (18 residues), see Phobius details amino acids 30 to 47 (18 residues), see Phobius details amino acids 142 to 163 (22 residues), see Phobius details amino acids 175 to 196 (22 residues), see Phobius details PF01435: Peptidase_M48" amino acids 71 to 277 (207 residues), 122.2 bits, see alignment E=1.2e-39

Best Hits

Swiss-Prot: 100% identical to HTPX_RHIME: Protease HtpX homolog (htpX) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 100% identity to smk:Sinme_3316)

Predicted SEED Role

"Probable protease htpX homolog (EC 3.4.24.-)" (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92KX3 at UniProt or InterPro

Protein Sequence (319 amino acids)

>SMc04091 heat shock protein HtpX (Sinorhizobium meliloti 1021)
MNLMRTAMLLAFMTVLFMAVGYVIGGRGGMMIALVIAAGMNFFSYWNSDRMVLRMYRAQE
VDEHSAPEYYGIVRDLAKNAGLPMPRVYVIDSPQPNAFATGRNPENAAVAASTGLLHSLS
YEEVAGVMAHELAHIQYRDTLTMTLTATLAGAISMLGNFAFFFGGNRENNNPLGFIGVLI
AMIVAPLAAMLVQMAISRTREYSADRRGAEICGNPLWLSSALRKIAGAAQVIHNNDAERN
PATAHMFIINPLSGERMDNLFSTHPNTENRVAALERMARETSTGSTAPVRPDNAGRKSRS
VPRTGWGRGGSEPPKGPWS