Protein Info for SMc03870 in Sinorhizobium meliloti 1021

Annotation: thiamine transporter membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 535 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 50 to 71 (22 residues), see Phobius details amino acids 83 to 106 (24 residues), see Phobius details amino acids 126 to 146 (21 residues), see Phobius details amino acids 186 to 208 (23 residues), see Phobius details amino acids 234 to 256 (23 residues), see Phobius details amino acids 285 to 303 (19 residues), see Phobius details amino acids 323 to 343 (21 residues), see Phobius details amino acids 364 to 389 (26 residues), see Phobius details amino acids 400 to 421 (22 residues), see Phobius details amino acids 433 to 450 (18 residues), see Phobius details amino acids 459 to 481 (23 residues), see Phobius details amino acids 502 to 524 (23 residues), see Phobius details TIGR01253: thiamine/thiamine pyrophosphate ABC transporter, permease protein" amino acids 9 to 519 (511 residues), 406.7 bits, see alignment E=9.8e-126

Best Hits

KEGG orthology group: K02063, thiamine transport system permease protein (inferred from 100% identity to sme:SMc03870)

Predicted SEED Role

"Thiamin ABC transporter, transmembrane component" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92L32 at UniProt or InterPro

Protein Sequence (535 amino acids)

>SMc03870 thiamine transporter membrane protein (Sinorhizobium meliloti 1021)
MTIAAGAFALGGILLFVGLAGAALLGQSAGSAGGGPLFDAYIWRITRFTLLQASLSTLLA
ILFAIPVARALARQASFPGRIWVLRLLALPLGLPALVAALGLIEIWGRQGLLNRVLSAAG
LEQPVSIYGLSGILIAHVFFNMPLAARLMLAGIERIPAEYWRTSANLGMGSFATFRFIEW
PVIRGLLPGIAGLIFMLCATSFTLVLTLGGGPAASTIEVAIYQALRFDFDPPRAIALSAL
QVALTGALLLVLKLIAPAPLEGETSGRAIRRFDGASGLSRLADRIWLILAVILVGLPFAA
IAYSGSKADLVRLVSEPAFHRALAMSATIALVSATISVAIAALMIRTERLALAQRRPGAA
PRLFAGTIGASTSFILLVPPVVLGAGWFLLLRPFGDVARFAPAVVVAINALMALPFVHRV
LAPAMATHAARTARLAASLGIGGFHRLLWIDWPGLRKPLFVAFSFAMALSLGDLGAVALF
GSEDMVTLPYLLYSRMGSYRTADAAGLALVLGLLCLVLTVLGTAGEERPPEGKST