Protein Info for SMc03763 in Sinorhizobium meliloti 1021

Annotation: cytosine-specific methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00145: DNA_methylase" amino acids 5 to 414 (410 residues), 176.1 bits, see alignment E=6.7e-56 TIGR00675: DNA (cytosine-5-)-methyltransferase" amino acids 6 to 414 (409 residues), 152.7 bits, see alignment E=9.9e-49

Best Hits

KEGG orthology group: K00558, DNA (cytosine-5-)-methyltransferase [EC: 2.1.1.37] (inferred from 100% identity to sme:SMc03763)

Predicted SEED Role

"Modification methylase DdeI"

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q92LC3 at UniProt or InterPro

Protein Sequence (440 amino acids)

>SMc03763 cytosine-specific methyltransferase (Sinorhizobium meliloti 1021)
MKKYSFADLFSGCGGLSLGLTQAGLKGQFAIERDAMAFRTFATNFIDARGASDRFEWPAW
LERRAWGIEELLEYHGKELLGLRGTIDVLAGGPPCQGFSFAGRRNEDDPRNLLFKKYVEM
VEALQPQALVIENVPGMRVAHARRNVVELQAADPGGRKISFYDKLVESLSAAGYDVDAML
VDSASFGVPQKRSRLIAIGVSKDLCKWLDGGILRAFKLLEEARVEQLAELGLPPLVTASD
AISDLEITGRPLVECVDPESPKRFMEASYGGPRTPYQTLMHHAHVGSMDSMRLARHTDEV
KDRFAKILAECRKGVRMDDASRRTYGLKKHRIYPMAEREPAPTVTTLPDDILHYREPRIL
TVRECARLQSFPDRFIFKGKYTTGGERRTKECPRYTQVGNAVPPLLARAIGNALTRLLDE
VSVAQLDSDNAATQLALTMA