Protein Info for SMc03116 in Sinorhizobium meliloti 1021
Annotation: alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: None (inferred from 100% identity to smk:Sinme_3032)MetaCyc: 63% identical to 3-hydroxypropionate dehydrogenase (Halomonas sp. HTNK1)
3-hydroxypropionate dehydrogenase. [EC: 1.1.1.59]
Predicted SEED Role
"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)
MetaCyc Pathways
- superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
- choline-O-sulfate degradation (3/3 steps found)
- β-alanine biosynthesis II (5/6 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- acrylate degradation I (4/5 steps found)
- propanoyl-CoA degradation II (4/5 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.99.1
Use Curated BLAST to search for 1.1.1.59 or 1.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q92LQ3 at UniProt or InterPro
Protein Sequence (531 amino acids)
>SMc03116 alcohol dehydrogenase (Sinorhizobium meliloti 1021) MDTFDYIIVGAGSAGCVLANRLSEDPDRRVLLLEAGGSDNYHWIHIPVGYLYCINNPRTD WCFTTAAEEGLNGRSLGYPRGKVLGGCSSINGMIYMRGQARDYDLWRQLGCPGWSWNDVL PFFRKSENHYRGADDMHGASGEWRVEKARVRWAVLDAFQKAATEAGIPETDDFNRGNNEG SGYFDVNQRSGIRWNTAKAFLKPARNRRNLTILTKAHVRRLILEDGRVAGVEFQHDGTVK SARARRETVLSAGAIGSPHILELSGIGRPDVLHENGIEVRHELPSVGENLQDHLQLRLAY KVTGVPTLNEKATSLFGKAAIGLEYLVRRSGPMAMAPSQLGIFTRSGPEKETPDLQYHVQ PVTLEKFGEPVHPFPAVTASVCNLRPESRGSVHLKGPDFAAAPDIRPRYLTAEADRDVAV KSIRLTRRIVAQPAFARYKPVEFKPGPDYQTDEELKRAAGDIGTTIFHPVGTCRMGSDPD SVVDPELRLRGIAGLRIADASIMPTITSGNTNSPTIMIAEKAAEMILAAGR