Protein Info for SMc03068 in Sinorhizobium meliloti 1021

Annotation: phosphogluconate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 TIGR01196: phosphogluconate dehydratase" amino acids 4 to 604 (601 residues), 1115 bits, see alignment E=0 PF00920: ILVD_EDD" amino acids 68 to 600 (533 residues), 520 bits, see alignment E=3.5e-160

Best Hits

Swiss-Prot: 100% identical to EDD_RHIME: Phosphogluconate dehydratase (edd) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01690, phosphogluconate dehydratase [EC: 4.2.1.12] (inferred from 100% identity to sme:SMc03068)

MetaCyc: 60% identical to phosphogluconate dehydratase (Escherichia coli K-12 substr. MG1655)
Phosphogluconate dehydratase. [EC: 4.2.1.12]

Predicted SEED Role

"Phosphogluconate dehydratase (EC 4.2.1.12)" in subsystem Entner-Doudoroff Pathway (EC 4.2.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q9Z3S0 at UniProt or InterPro

Protein Sequence (606 amino acids)

>SMc03068 phosphogluconate dehydratase (Sinorhizobium meliloti 1021)
MSADSRIAAITARIVERSKPYREPYLDRVRSAATNGPHRTVLGCGNLAHGFAVCSPAEKV
ALAGDRVPNLGIITSYNDMLSAHQPFETYPALIREAAHEAGGVAQVAGGVPAMCDGVTQG
QPGMELSLFSRDVIAMAAGIGLSHNMFDAAVYLGVCDKIVPGLAIAALTFGHLPAVFIPA
GPMTTGLPNDEKAKVRQLFAEGKVGRDELLEAESKSYHGPGTCTFYGTANSNQMLMEIMG
FHLPGASFINPGTPLRDALTREATKRALAITALGNEFTPAGEMIDERSIVNGVVGLHATG
GSTNHTMHLVAMARAAGIVLTWQDISELSDLVPLLARVYPNGLADVNHFHAAGGMGFLIA
QLLRKGLLHDDVRTVYGQGLSAYAIDVKLGENGSVKREPAPEASADPKVLATVDRPFQHT
GGLKMLSGNIGKAVIKISAVKPESHVIEAPAKIFNDQAELNAAFKAGKLEGDFVAVVRFQ
GPKANGMPELHKLTTVLGILQDRGQKVAILTDGRMSGASGKVPAAIHVTPEAKEGGPIAR
IQEGDIVRIDAINGKVEVLVEDIALKTRVPAHIDLSDNEFGMGRELFAPFRQIAGAADRG
GSVLFH